Muscle torque relative to cross-sectional area and the functional muscle-bone unit in children and adolescents with chronic disease

Dale Y. Lee, Rachel J. Wetzsteon, Babette S. Zemel, Justine Shults, Jason M. Organ, Bethany J. Foster, Rita M. Herskovitz, Debbie L. Foerster, Mary B. Leonard

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Measures of muscle mass or size are often used as surrogates of forces acting on bone. However, chronic diseases may be associated with abnormal muscle force relative to muscle size. The muscle-bone unit was examined in 64 children and adolescents with newonset Crohn's disease (CD), 54 with chronic kidney disease (CKD), 51 treated with glucocorticoids for nephrotic syndrome (NS), and 264 healthy controls. Muscle torque was assessed by isometric ankle dynamometry. Calf muscle cross-sectional area (CSA) and tibia cortical section modulus (Zp) were assessed by quantitative CT. Log-linear regression was used to determine the relations among muscle CSA, muscle torque, and Zp, adjusted for tibia length, age, Tanner stage, sex, and race. Muscle CSA and muscle torquerelative- to-muscle CSA were significantly lower than controls in advanced CKD (CSA -8.7%, p=0.01; torque -22.9%, p<0.001) and moderate-to-severe CD (CSA -14.1%, p<0.001; torque -7.6%, p=0.05), but not in NS. Zp was 11.5% lower in advanced CKD (p=0.005) compared to controls, and this deficit was attenuated to 6.7% (p=0.05) with adjustment for muscle CSA. With additional adjustment for muscle torque and body weight, Zp was 5.9% lower and the difference with controls was no longer significant (p=0.09). In participants with moderate-to-severe CD, Zp was 6.8% greater than predicted (p=0.01) given muscle CSA and torque deficits (R2=0.92), likely due to acute muscle loss in newly-diagnosed patients. Zp did not differ in NS, compared with controls. In conclusion, muscle torque relative to muscle CSA was significantly lower in CKD and CD, compared with controls, and was independently associated with Zp. Future studies are needed to determine if abnormal muscle strength contributes to progressive bone deficits in chronic disease, independent of muscle area.

Original languageEnglish (US)
Pages (from-to)563-571
Number of pages9
JournalJournal of Bone and Mineral Research
Volume30
Issue number3
DOIs
StatePublished - Mar 1 2015

Fingerprint

Torque
Chronic Disease
Bone and Bones
Muscles
Tibia
Chronic Renal Insufficiency
Nephrotic Syndrome
Ankle
Crohn Disease
Glucocorticoids
Linear Models

Keywords

  • Bone
  • Children
  • Crohn's disease
  • Glucocorticoids
  • Kidney disease
  • Muscle
  • Peripheral quantitative computed tomography

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

Cite this

Muscle torque relative to cross-sectional area and the functional muscle-bone unit in children and adolescents with chronic disease. / Lee, Dale Y.; Wetzsteon, Rachel J.; Zemel, Babette S.; Shults, Justine; Organ, Jason M.; Foster, Bethany J.; Herskovitz, Rita M.; Foerster, Debbie L.; Leonard, Mary B.

In: Journal of Bone and Mineral Research, Vol. 30, No. 3, 01.03.2015, p. 563-571.

Research output: Contribution to journalArticle

Lee, DY, Wetzsteon, RJ, Zemel, BS, Shults, J, Organ, JM, Foster, BJ, Herskovitz, RM, Foerster, DL & Leonard, MB 2015, 'Muscle torque relative to cross-sectional area and the functional muscle-bone unit in children and adolescents with chronic disease', Journal of Bone and Mineral Research, vol. 30, no. 3, pp. 563-571. https://doi.org/10.1002/jbmr.2375
Lee, Dale Y. ; Wetzsteon, Rachel J. ; Zemel, Babette S. ; Shults, Justine ; Organ, Jason M. ; Foster, Bethany J. ; Herskovitz, Rita M. ; Foerster, Debbie L. ; Leonard, Mary B. / Muscle torque relative to cross-sectional area and the functional muscle-bone unit in children and adolescents with chronic disease. In: Journal of Bone and Mineral Research. 2015 ; Vol. 30, No. 3. pp. 563-571.
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abstract = "Measures of muscle mass or size are often used as surrogates of forces acting on bone. However, chronic diseases may be associated with abnormal muscle force relative to muscle size. The muscle-bone unit was examined in 64 children and adolescents with newonset Crohn's disease (CD), 54 with chronic kidney disease (CKD), 51 treated with glucocorticoids for nephrotic syndrome (NS), and 264 healthy controls. Muscle torque was assessed by isometric ankle dynamometry. Calf muscle cross-sectional area (CSA) and tibia cortical section modulus (Zp) were assessed by quantitative CT. Log-linear regression was used to determine the relations among muscle CSA, muscle torque, and Zp, adjusted for tibia length, age, Tanner stage, sex, and race. Muscle CSA and muscle torquerelative- to-muscle CSA were significantly lower than controls in advanced CKD (CSA -8.7{\%}, p=0.01; torque -22.9{\%}, p<0.001) and moderate-to-severe CD (CSA -14.1{\%}, p<0.001; torque -7.6{\%}, p=0.05), but not in NS. Zp was 11.5{\%} lower in advanced CKD (p=0.005) compared to controls, and this deficit was attenuated to 6.7{\%} (p=0.05) with adjustment for muscle CSA. With additional adjustment for muscle torque and body weight, Zp was 5.9{\%} lower and the difference with controls was no longer significant (p=0.09). In participants with moderate-to-severe CD, Zp was 6.8{\%} greater than predicted (p=0.01) given muscle CSA and torque deficits (R2=0.92), likely due to acute muscle loss in newly-diagnosed patients. Zp did not differ in NS, compared with controls. In conclusion, muscle torque relative to muscle CSA was significantly lower in CKD and CD, compared with controls, and was independently associated with Zp. Future studies are needed to determine if abnormal muscle strength contributes to progressive bone deficits in chronic disease, independent of muscle area.",
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AU - Shults, Justine

AU - Organ, Jason M.

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AU - Leonard, Mary B.

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N2 - Measures of muscle mass or size are often used as surrogates of forces acting on bone. However, chronic diseases may be associated with abnormal muscle force relative to muscle size. The muscle-bone unit was examined in 64 children and adolescents with newonset Crohn's disease (CD), 54 with chronic kidney disease (CKD), 51 treated with glucocorticoids for nephrotic syndrome (NS), and 264 healthy controls. Muscle torque was assessed by isometric ankle dynamometry. Calf muscle cross-sectional area (CSA) and tibia cortical section modulus (Zp) were assessed by quantitative CT. Log-linear regression was used to determine the relations among muscle CSA, muscle torque, and Zp, adjusted for tibia length, age, Tanner stage, sex, and race. Muscle CSA and muscle torquerelative- to-muscle CSA were significantly lower than controls in advanced CKD (CSA -8.7%, p=0.01; torque -22.9%, p<0.001) and moderate-to-severe CD (CSA -14.1%, p<0.001; torque -7.6%, p=0.05), but not in NS. Zp was 11.5% lower in advanced CKD (p=0.005) compared to controls, and this deficit was attenuated to 6.7% (p=0.05) with adjustment for muscle CSA. With additional adjustment for muscle torque and body weight, Zp was 5.9% lower and the difference with controls was no longer significant (p=0.09). In participants with moderate-to-severe CD, Zp was 6.8% greater than predicted (p=0.01) given muscle CSA and torque deficits (R2=0.92), likely due to acute muscle loss in newly-diagnosed patients. Zp did not differ in NS, compared with controls. In conclusion, muscle torque relative to muscle CSA was significantly lower in CKD and CD, compared with controls, and was independently associated with Zp. Future studies are needed to determine if abnormal muscle strength contributes to progressive bone deficits in chronic disease, independent of muscle area.

AB - Measures of muscle mass or size are often used as surrogates of forces acting on bone. However, chronic diseases may be associated with abnormal muscle force relative to muscle size. The muscle-bone unit was examined in 64 children and adolescents with newonset Crohn's disease (CD), 54 with chronic kidney disease (CKD), 51 treated with glucocorticoids for nephrotic syndrome (NS), and 264 healthy controls. Muscle torque was assessed by isometric ankle dynamometry. Calf muscle cross-sectional area (CSA) and tibia cortical section modulus (Zp) were assessed by quantitative CT. Log-linear regression was used to determine the relations among muscle CSA, muscle torque, and Zp, adjusted for tibia length, age, Tanner stage, sex, and race. Muscle CSA and muscle torquerelative- to-muscle CSA were significantly lower than controls in advanced CKD (CSA -8.7%, p=0.01; torque -22.9%, p<0.001) and moderate-to-severe CD (CSA -14.1%, p<0.001; torque -7.6%, p=0.05), but not in NS. Zp was 11.5% lower in advanced CKD (p=0.005) compared to controls, and this deficit was attenuated to 6.7% (p=0.05) with adjustment for muscle CSA. With additional adjustment for muscle torque and body weight, Zp was 5.9% lower and the difference with controls was no longer significant (p=0.09). In participants with moderate-to-severe CD, Zp was 6.8% greater than predicted (p=0.01) given muscle CSA and torque deficits (R2=0.92), likely due to acute muscle loss in newly-diagnosed patients. Zp did not differ in NS, compared with controls. In conclusion, muscle torque relative to muscle CSA was significantly lower in CKD and CD, compared with controls, and was independently associated with Zp. Future studies are needed to determine if abnormal muscle strength contributes to progressive bone deficits in chronic disease, independent of muscle area.

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