MYCN is the only highly expressed gene from the core amplified domain in human neuroblastomas

Jill L. Reiter, Garrett M. Brodeur

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


MYCN amplification in neuroblastomas is strongly associated with advanced stages of disease and a poor prognosis. We have recently defined a 130 kb core region of the MYCN amplicon that is consistently amplified in neuroblastomas. However, it has been argued that other expressed sequences were coamplified with MYCN and, as a result, might contribute to the aggressive phenotype of MYCN-amplified neuroblastomas. Therefore, we have screened cosmids representing the core MYCN-amplified domain and surrounding DNA by using a differential hybridization approach to detect other amplified, highly expressed genes from this region. Our results suggest that MYCN is the only highly expressed gene consistently amplified in human neuroblastomas, and that the MYCN gene is likely to be the only selective marker for genomic amplification in these tumors.

Original languageEnglish (US)
Pages (from-to)134-140
Number of pages7
JournalGenes Chromosomes and Cancer
Issue number2
StatePublished - Oct 1998

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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