Myelinoid lamellated cytoplasmic inclusions in human renal adenocarcinomas: An ultrastructural study

Meredith T. Hull, John Eble

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Ultrastructural study of 2 human renal adenocarcinomas demonstrated abundant myelinoid lamellated cytoplasmic inclusions, which were restricted to the neoplastic cells. They were structurally similar to those reported in renal adenocarcinomas chemically induced in rats; to those described in human diseases involving defects in lipid metabolism, including Gm2 gangliosidosis, Fabry's disease, Nieman-Pick disease, and juvenile-type neuronal ceroid-lipofuscinosis. Similar inclusions have also been reported to be induced by several drugs, none of which were taken by these patients. The occurrence of these lamellated inclusions in 2 human renal adenocarcinomas reinforces the phonotypic similarity between nitrosomorpholine-induced renal adenocarcinomas in rats and some renal adenocarcinomas seen in humans.

Original languageEnglish
Pages (from-to)41-48
Number of pages8
JournalUltrastructural Pathology
Volume12
Issue number1
DOIs
StatePublished - 1988

Fingerprint

Inclusion Bodies
Renal Cell Carcinoma
inclusions
rats
Rats
lipid metabolism
Gangliosidoses
Pick Disease of the Brain
Neuronal Ceroid-Lipofuscinoses
drugs
Fabry Disease
occurrences
Defects
Lipid Metabolism
defects
cells
Pharmaceutical Preparations

Keywords

  • Myelinoid lamellated inclusions
  • Renal adenocarcinoma
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology
  • Instrumentation

Cite this

Myelinoid lamellated cytoplasmic inclusions in human renal adenocarcinomas : An ultrastructural study. / Hull, Meredith T.; Eble, John.

In: Ultrastructural Pathology, Vol. 12, No. 1, 1988, p. 41-48.

Research output: Contribution to journalArticle

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