Myelodysplastic syndromes

Attilio Orazi, Magdalena Czader

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Session 4 of the 2007 Workshop of the Society for Hematopathology/European Association for Haematopathology was devoted to myelodysplastic syndromes (MDSs). Submitted cases highlighted important issues and difficulties in relation to the diagnosis and classification of MDS. Much of the discussion focused on the correlation, or lack of it, between morphologic examination and other diagnostic techniques, cytogenetics in particular. The cases included examples of isolated del(5q) chromosomal abnormality, including the "classical" 5q- syndrome and other myeloid neoplasms. Other cytogenetic abnormalities in MDSs and the role of cytogenetics in diagnosing MDSs were addressed. Particularly challenging is the correct identification of fibrotic subtypes of MDSs and their separation from subsets of acute myeloid leukemia with myelofibrosis such as acute panmyelosis with myelofibrosis. The association and eventual relation of MDSs (hypoplastic in particular) with aplastic anemia, paroxysmal nocturnal hemoglobinuria, and other nonneoplastic disorders were illustrated. Novel cytogenetic and molecular genetic approaches are likely to revolutionize the classification of MDSs. However, it is unlikely that these new techniques will be capable, on their own, of adequately stratifying patients for treatment purposes. At least for the foreseeable future, the diagnosis of MDS requires integration of morphologic, immunophenotypic, and genetic features in the light of patient history and clinical manifestations.

Original languageEnglish
Pages (from-to)290-305
Number of pages16
JournalAmerican Journal of Clinical Pathology
Volume132
Issue number2
DOIs
StatePublished - Aug 2009

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Myelodysplastic Syndromes
Primary Myelofibrosis
Cytogenetics
Chromosome Aberrations
Paroxysmal Hemoglobinuria
Aplastic Anemia
Cytogenetic Analysis
Acute Myeloid Leukemia
Molecular Biology
Education

Keywords

  • MDS associated with an isolated del(5q) chromosomal abnormality
  • Myelodysplastic syndrome
  • Refractory anemia with excess blasts
  • Refractory anemia with ring sideroblasts
  • Refractory cytopenia with multilineage dysplasia
  • Refractory cytopenia with unilineage dysplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Myelodysplastic syndromes. / Orazi, Attilio; Czader, Magdalena.

In: American Journal of Clinical Pathology, Vol. 132, No. 2, 08.2009, p. 290-305.

Research output: Contribution to journalArticle

Orazi, Attilio ; Czader, Magdalena. / Myelodysplastic syndromes. In: American Journal of Clinical Pathology. 2009 ; Vol. 132, No. 2. pp. 290-305.
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