Myeloid marker expression on antiviral CD8+ T cells following an acute virus infection

Yinling Lin, Tonya J. Roberts, Venkataraman Sriram, Sungyoo Cho, Randy Brutkiewicz

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

CD11b, CD11c, and F4/80 are normally used to define dendritic cell and/or macrophage populations. In this study, the expression of all three markers was observed on CD8+ T cells following infection of mice with several distinct viruses. Using lymphocytic choriomeningitis virus as a model virus, it was found that relatively more CD11b+CD8+ and CD11c+CD8+ T cells were present in the periphery than in primary lymphoid organs; in contrast, the F4/80+CD8+ T cell population was more prevalent in the spleen. All three myeloid markers were detected on virus-specific CTL. The expression of CD11b and CD11c on CD8+ T cells correlated with their level of CTL activity, whereas the F4/80+CD8+ T cell population increased after the peak of the CTL response but did not have higher CTL activity. These data suggest that there is a differential induction of CD11b, CD11c, and F4/80 on virus-specific CD8+ T cells following an acute virus infection.

Original languageEnglish
Pages (from-to)2736-2743
Number of pages8
JournalEuropean Journal of Immunology
Volume33
Issue number10
DOIs
StatePublished - Oct 2003

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Virus Diseases
Antiviral Agents
T-Lymphocytes
Viruses
Population
Lymphocytic choriomeningitis virus
Dendritic Cells
Spleen
Macrophages
Infection

Keywords

  • Cell surface molecules
  • Cellular activation
  • CTL
  • Viral

ASJC Scopus subject areas

  • Immunology

Cite this

Myeloid marker expression on antiviral CD8+ T cells following an acute virus infection. / Lin, Yinling; Roberts, Tonya J.; Sriram, Venkataraman; Cho, Sungyoo; Brutkiewicz, Randy.

In: European Journal of Immunology, Vol. 33, No. 10, 10.2003, p. 2736-2743.

Research output: Contribution to journalArticle

Lin, Yinling ; Roberts, Tonya J. ; Sriram, Venkataraman ; Cho, Sungyoo ; Brutkiewicz, Randy. / Myeloid marker expression on antiviral CD8+ T cells following an acute virus infection. In: European Journal of Immunology. 2003 ; Vol. 33, No. 10. pp. 2736-2743.
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