Myocardial clearance kinetics of technetium-99m-SQ30217: A marker of regional myocardial blood flow

R. E. Stewart, M. Schwaiger, G. D. Hutchins, P. C. Chiao, K. P. Gallagher, N. Nguyen, N. A. Petry, W. L. Rogers

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Abstract

SQ30217 is a new, technetium-99m- (99mTc) labeled perfusion agent introduced for cardiac imaging. To evaluate the myocardial tracer kinetics, 99mTc-SQ30217 was injected intracoronarily in open-chested dogs under baseline conditions and after administration of intravenous (i.v.) dipyridamole. Myocardial first-pass retention fraction averated 0.90 ± 0.04. Clearance of the tracer occurred in a biexponential manner. Sixty-seven percent of retained activity cleared with a half-time of 2.3 ± 0.6 min, while the residual activity demonstrated slow clearance. The clearance rate of the rapid phase correlated with myocardial blood flow (r = 0.72, p < 0.001). Myocardial SQ30217 clearance rate following i.v. injection as determined by dynamic imaging with tomography (SPRINT) averaged 21 ± 4 min and increased to 13 ± 4 min following dipyridamole. Thus, 99mTc-SQ30217 is a promising flow tracer with high initial myocardial retention and rapid tissue clearance, which allow repeated flow determinations within short time intervals using advanced SPECT technology.

Original languageEnglish (US)
Pages (from-to)1183-1190
Number of pages8
JournalJournal of Nuclear Medicine
Volume31
Issue number7
StatePublished - Jan 1 1990

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Stewart, R. E., Schwaiger, M., Hutchins, G. D., Chiao, P. C., Gallagher, K. P., Nguyen, N., Petry, N. A., & Rogers, W. L. (1990). Myocardial clearance kinetics of technetium-99m-SQ30217: A marker of regional myocardial blood flow. Journal of Nuclear Medicine, 31(7), 1183-1190.