Myocardial clearance kinetics of technetium-99m-SQ30217: A marker of regional myocardial blood flow

R. E. Stewart, M. Schwaiger, G. D. Hutchins, P. C. Chiao, K. P. Gallagher, N. Nguyen, N. A. Petry, W. L. Rogers

Research output: Contribution to journalArticle

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Abstract

SQ30217 is a new, technetium-99m- (99mTc) labeled perfusion agent introduced for cardiac imaging. To evaluate the myocardial tracer kinetics, 99mTc-SQ30217 was injected intracoronarily in open-chested dogs under baseline conditions and after administration of intravenous (i.v.) dipyridamole. Myocardial first-pass retention fraction averated 0.90 ± 0.04. Clearance of the tracer occurred in a biexponential manner. Sixty-seven percent of retained activity cleared with a half-time of 2.3 ± 0.6 min, while the residual activity demonstrated slow clearance. The clearance rate of the rapid phase correlated with myocardial blood flow (r = 0.72, p < 0.001). Myocardial SQ30217 clearance rate following i.v. injection as determined by dynamic imaging with tomography (SPRINT) averaged 21 ± 4 min and increased to 13 ± 4 min following dipyridamole. Thus, 99mTc-SQ30217 is a promising flow tracer with high initial myocardial retention and rapid tissue clearance, which allow repeated flow determinations within short time intervals using advanced SPECT technology.

Original languageEnglish (US)
Pages (from-to)1183-1190
Number of pages8
JournalJournal of Nuclear Medicine
Volume31
Issue number7
StatePublished - Jan 1 1990

Fingerprint

Dipyridamole
Technetium
Regional Blood Flow
Single-Photon Emission-Computed Tomography
Intravenous Injections
Intravenous Administration
Thorax
Perfusion
Tomography
Dogs
Technology

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Stewart, R. E., Schwaiger, M., Hutchins, G. D., Chiao, P. C., Gallagher, K. P., Nguyen, N., ... Rogers, W. L. (1990). Myocardial clearance kinetics of technetium-99m-SQ30217: A marker of regional myocardial blood flow. Journal of Nuclear Medicine, 31(7), 1183-1190.

Myocardial clearance kinetics of technetium-99m-SQ30217 : A marker of regional myocardial blood flow. / Stewart, R. E.; Schwaiger, M.; Hutchins, G. D.; Chiao, P. C.; Gallagher, K. P.; Nguyen, N.; Petry, N. A.; Rogers, W. L.

In: Journal of Nuclear Medicine, Vol. 31, No. 7, 01.01.1990, p. 1183-1190.

Research output: Contribution to journalArticle

Stewart, RE, Schwaiger, M, Hutchins, GD, Chiao, PC, Gallagher, KP, Nguyen, N, Petry, NA & Rogers, WL 1990, 'Myocardial clearance kinetics of technetium-99m-SQ30217: A marker of regional myocardial blood flow', Journal of Nuclear Medicine, vol. 31, no. 7, pp. 1183-1190.
Stewart RE, Schwaiger M, Hutchins GD, Chiao PC, Gallagher KP, Nguyen N et al. Myocardial clearance kinetics of technetium-99m-SQ30217: A marker of regional myocardial blood flow. Journal of Nuclear Medicine. 1990 Jan 1;31(7):1183-1190.
Stewart, R. E. ; Schwaiger, M. ; Hutchins, G. D. ; Chiao, P. C. ; Gallagher, K. P. ; Nguyen, N. ; Petry, N. A. ; Rogers, W. L. / Myocardial clearance kinetics of technetium-99m-SQ30217 : A marker of regional myocardial blood flow. In: Journal of Nuclear Medicine. 1990 ; Vol. 31, No. 7. pp. 1183-1190.
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