Myocardial infarction/injury is relatively common at presentation of acute thrombotic thrombocytopenic purpura: The Indiana University experience

Leo J. McCarthy, Constance F.M. Danielson, Elaine M. Skipworth, Shelley L. Peters, Charles C. Miraglia, Asok C. Antony

Research output: Contribution to journalArticle

41 Scopus citations


Although widespread vascular thrombosis is common in thrombotic thrombocytopenic purpura (TTP), there have been no prospective studies on the extent of injury to specific organs. Following successful resuscitation and plasma exchange of an index patient with widespread organ dysfunction, cardiogenic shock, and elevated cardiac troponin-I levels, we prospectively studied and identified 2 more individuals (of 10 consecutive patients) with evidence of myocardial injury/infarction at presentation of acute TTP. These data suggest that cardiac troponin-I measurements should be considered during initial evaluation of all patients with acute TTP.

Original languageEnglish (US)
Pages (from-to)2-4
Number of pages3
JournalTherapeutic Apheresis
Issue number1
StatePublished - Mar 23 2002



  • Cardiac troponin-I
  • Cardiogenic shock
  • Myocardial infarction
  • Plasma exchange
  • Solvent detergent plasma
  • Thrombotic thrombocytopenic purpura

ASJC Scopus subject areas

  • Medicine(all)

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