Myocardial regeneration via cell cycle activation

Pascal J. LaFontant, Loren Field

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Introduction During development, increases in heart size results as a consequence of the differentiation and proliferation of cardiomyocytes, neurons, interstitial cells, and components of the vasculature. At birth, cardiomyocytes undergo a gradual transition from hyperplastic to hypertrophic growth, such that subsequent increases in myocardial mass result largely from increased myocyte size rather than increased number. In contrast, the other cell types present in the heart retain the ability to proliferate. Consequently, in adults, although cardiomyocytes constitute approximately 90% of the mass of the heart, they constitute less than 20% of the total number of cells present.

Original languageEnglish (US)
Title of host publicationRebuilding the Infarcted Heart
PublisherCRC Press
Pages41-53
Number of pages13
ISBN (Electronic)9780203089736
ISBN (Print)9780415419246
StatePublished - Jan 1 2007

Fingerprint

Cardiac Myocytes
Regeneration
Cell Cycle
Cellular Structures
Muscle Cells
Cell Count
Parturition
Neurons
Growth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

LaFontant, P. J., & Field, L. (2007). Myocardial regeneration via cell cycle activation. In Rebuilding the Infarcted Heart (pp. 41-53). CRC Press.

Myocardial regeneration via cell cycle activation. / LaFontant, Pascal J.; Field, Loren.

Rebuilding the Infarcted Heart. CRC Press, 2007. p. 41-53.

Research output: Chapter in Book/Report/Conference proceedingChapter

LaFontant, PJ & Field, L 2007, Myocardial regeneration via cell cycle activation. in Rebuilding the Infarcted Heart. CRC Press, pp. 41-53.
LaFontant PJ, Field L. Myocardial regeneration via cell cycle activation. In Rebuilding the Infarcted Heart. CRC Press. 2007. p. 41-53
LaFontant, Pascal J. ; Field, Loren. / Myocardial regeneration via cell cycle activation. Rebuilding the Infarcted Heart. CRC Press, 2007. pp. 41-53
@inbook{512275a1e01e48e088b8da8a702aee88,
title = "Myocardial regeneration via cell cycle activation",
abstract = "Introduction During development, increases in heart size results as a consequence of the differentiation and proliferation of cardiomyocytes, neurons, interstitial cells, and components of the vasculature. At birth, cardiomyocytes undergo a gradual transition from hyperplastic to hypertrophic growth, such that subsequent increases in myocardial mass result largely from increased myocyte size rather than increased number. In contrast, the other cell types present in the heart retain the ability to proliferate. Consequently, in adults, although cardiomyocytes constitute approximately 90{\%} of the mass of the heart, they constitute less than 20{\%} of the total number of cells present.",
author = "LaFontant, {Pascal J.} and Loren Field",
year = "2007",
month = "1",
day = "1",
language = "English (US)",
isbn = "9780415419246",
pages = "41--53",
booktitle = "Rebuilding the Infarcted Heart",
publisher = "CRC Press",

}

TY - CHAP

T1 - Myocardial regeneration via cell cycle activation

AU - LaFontant, Pascal J.

AU - Field, Loren

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Introduction During development, increases in heart size results as a consequence of the differentiation and proliferation of cardiomyocytes, neurons, interstitial cells, and components of the vasculature. At birth, cardiomyocytes undergo a gradual transition from hyperplastic to hypertrophic growth, such that subsequent increases in myocardial mass result largely from increased myocyte size rather than increased number. In contrast, the other cell types present in the heart retain the ability to proliferate. Consequently, in adults, although cardiomyocytes constitute approximately 90% of the mass of the heart, they constitute less than 20% of the total number of cells present.

AB - Introduction During development, increases in heart size results as a consequence of the differentiation and proliferation of cardiomyocytes, neurons, interstitial cells, and components of the vasculature. At birth, cardiomyocytes undergo a gradual transition from hyperplastic to hypertrophic growth, such that subsequent increases in myocardial mass result largely from increased myocyte size rather than increased number. In contrast, the other cell types present in the heart retain the ability to proliferate. Consequently, in adults, although cardiomyocytes constitute approximately 90% of the mass of the heart, they constitute less than 20% of the total number of cells present.

UR - http://www.scopus.com/inward/record.url?scp=84855483139&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855483139&partnerID=8YFLogxK

M3 - Chapter

SN - 9780415419246

SP - 41

EP - 53

BT - Rebuilding the Infarcted Heart

PB - CRC Press

ER -