Myocardial repolarization dispersion and autonomic nerve activity in a canine experimental acute myocardial infarction model

Gianfranco Piccirillo, Federica Moscucci, Gaetana D'Alessandro, Matteo Pascucci, Pietro Rossi, Seongwook Han, Lan Chen, Shien-Fong Lin, Peng-Sheng Chen, Damiano Magrì

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Abstract

Background Evidence from a canine experimental acute myocardial infarction (MI) model shows that until the seventh week after MI, the relationship between stellate ganglion nerve activity (SGNA) and vagal nerve activity (VNA) progressively increases. Objective The purpose of this study was to evaluate how autonomic nervous system activity influences temporal myocardial repolarization dispersion at this period. Methods We analyzed autonomic nerve activity as well as QT and RR variability from recordings previously obtained in nine dogs. From a total of 48 short-term ECG segments, 24 recorded before and 24 recorded 7 weeks after experimentally-induced MI, we obtained three indices of temporal myocardial repolarization dispersion: QTe (from Q-wave to T-wave end), QTp (from Q-wave to T-wave peak), and Te (from T-wave peak to T-wave end) variability index (QTeVI, QT pVI, TeVI). We also performed heart rate variability power spectral analysis on the same segments. Results After MI, all the QT variables increased QTeVI (median [interquartile range]) (from-1.76[0.82] to-1.32[0.68]), QTeVI (from-1.90[1.01] to-1.45[0.78]), and T eVI (from-0.72[0.67] to-0.22[1.00]), whereas all RR spectral indices decreased (P <.001 for all). Distinct circadian rhythms in QTeVI (P <.05,) QTpVI (P <.001) and TeVI (P <.05) appeared after MI with circadian variations resembling that of SGNA/VNA. The morning QTpVI and TeVI acrophases approached the SGNA/VNA acrophase. Conversely, the evening QTeVI acrophase coincided with another SGNA/VNA peak. After MI, regression analysis detected a positive relationship between SGNA/VNA and TeVI (R2: 0.077; β: 0.278; p< 0.001). Conclusion Temporal myocardial repolarization dispersion shows a circadian variation after MI reaching its peak at a time when sympathetic is highest and vagal activity lowest.

Original languageEnglish
Pages (from-to)110-118
Number of pages9
JournalHeart Rhythm
Volume11
Issue number1
DOIs
StatePublished - Jan 2014

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Autonomic Pathways
Stellate Ganglion
Canidae
Myocardial Infarction
Autonomic Nervous System
Circadian Rhythm
Electrocardiography
Heart Rate
Regression Analysis
Dogs

Keywords

  • Myocardial infarction
  • Sudden cardiac death
  • Temporal myocardial repolarization dispersion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Piccirillo, G., Moscucci, F., D'Alessandro, G., Pascucci, M., Rossi, P., Han, S., ... Magrì, D. (2014). Myocardial repolarization dispersion and autonomic nerve activity in a canine experimental acute myocardial infarction model. Heart Rhythm, 11(1), 110-118. https://doi.org/10.1016/j.hrthm.2013.10.022

Myocardial repolarization dispersion and autonomic nerve activity in a canine experimental acute myocardial infarction model. / Piccirillo, Gianfranco; Moscucci, Federica; D'Alessandro, Gaetana; Pascucci, Matteo; Rossi, Pietro; Han, Seongwook; Chen, Lan; Lin, Shien-Fong; Chen, Peng-Sheng; Magrì, Damiano.

In: Heart Rhythm, Vol. 11, No. 1, 01.2014, p. 110-118.

Research output: Contribution to journalArticle

Piccirillo, Gianfranco ; Moscucci, Federica ; D'Alessandro, Gaetana ; Pascucci, Matteo ; Rossi, Pietro ; Han, Seongwook ; Chen, Lan ; Lin, Shien-Fong ; Chen, Peng-Sheng ; Magrì, Damiano. / Myocardial repolarization dispersion and autonomic nerve activity in a canine experimental acute myocardial infarction model. In: Heart Rhythm. 2014 ; Vol. 11, No. 1. pp. 110-118.
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abstract = "Background Evidence from a canine experimental acute myocardial infarction (MI) model shows that until the seventh week after MI, the relationship between stellate ganglion nerve activity (SGNA) and vagal nerve activity (VNA) progressively increases. Objective The purpose of this study was to evaluate how autonomic nervous system activity influences temporal myocardial repolarization dispersion at this period. Methods We analyzed autonomic nerve activity as well as QT and RR variability from recordings previously obtained in nine dogs. From a total of 48 short-term ECG segments, 24 recorded before and 24 recorded 7 weeks after experimentally-induced MI, we obtained three indices of temporal myocardial repolarization dispersion: QTe (from Q-wave to T-wave end), QTp (from Q-wave to T-wave peak), and Te (from T-wave peak to T-wave end) variability index (QTeVI, QT pVI, TeVI). We also performed heart rate variability power spectral analysis on the same segments. Results After MI, all the QT variables increased QTeVI (median [interquartile range]) (from-1.76[0.82] to-1.32[0.68]), QTeVI (from-1.90[1.01] to-1.45[0.78]), and T eVI (from-0.72[0.67] to-0.22[1.00]), whereas all RR spectral indices decreased (P <.001 for all). Distinct circadian rhythms in QTeVI (P <.05,) QTpVI (P <.001) and TeVI (P <.05) appeared after MI with circadian variations resembling that of SGNA/VNA. The morning QTpVI and TeVI acrophases approached the SGNA/VNA acrophase. Conversely, the evening QTeVI acrophase coincided with another SGNA/VNA peak. After MI, regression analysis detected a positive relationship between SGNA/VNA and TeVI (R2: 0.077; β: 0.278; p< 0.001). Conclusion Temporal myocardial repolarization dispersion shows a circadian variation after MI reaching its peak at a time when sympathetic is highest and vagal activity lowest.",
keywords = "Myocardial infarction, Sudden cardiac death, Temporal myocardial repolarization dispersion",
author = "Gianfranco Piccirillo and Federica Moscucci and Gaetana D'Alessandro and Matteo Pascucci and Pietro Rossi and Seongwook Han and Lan Chen and Shien-Fong Lin and Peng-Sheng Chen and Damiano Magr{\`i}",
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AU - Piccirillo, Gianfranco

AU - Moscucci, Federica

AU - D'Alessandro, Gaetana

AU - Pascucci, Matteo

AU - Rossi, Pietro

AU - Han, Seongwook

AU - Chen, Lan

AU - Lin, Shien-Fong

AU - Chen, Peng-Sheng

AU - Magrì, Damiano

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N2 - Background Evidence from a canine experimental acute myocardial infarction (MI) model shows that until the seventh week after MI, the relationship between stellate ganglion nerve activity (SGNA) and vagal nerve activity (VNA) progressively increases. Objective The purpose of this study was to evaluate how autonomic nervous system activity influences temporal myocardial repolarization dispersion at this period. Methods We analyzed autonomic nerve activity as well as QT and RR variability from recordings previously obtained in nine dogs. From a total of 48 short-term ECG segments, 24 recorded before and 24 recorded 7 weeks after experimentally-induced MI, we obtained three indices of temporal myocardial repolarization dispersion: QTe (from Q-wave to T-wave end), QTp (from Q-wave to T-wave peak), and Te (from T-wave peak to T-wave end) variability index (QTeVI, QT pVI, TeVI). We also performed heart rate variability power spectral analysis on the same segments. Results After MI, all the QT variables increased QTeVI (median [interquartile range]) (from-1.76[0.82] to-1.32[0.68]), QTeVI (from-1.90[1.01] to-1.45[0.78]), and T eVI (from-0.72[0.67] to-0.22[1.00]), whereas all RR spectral indices decreased (P <.001 for all). Distinct circadian rhythms in QTeVI (P <.05,) QTpVI (P <.001) and TeVI (P <.05) appeared after MI with circadian variations resembling that of SGNA/VNA. The morning QTpVI and TeVI acrophases approached the SGNA/VNA acrophase. Conversely, the evening QTeVI acrophase coincided with another SGNA/VNA peak. After MI, regression analysis detected a positive relationship between SGNA/VNA and TeVI (R2: 0.077; β: 0.278; p< 0.001). Conclusion Temporal myocardial repolarization dispersion shows a circadian variation after MI reaching its peak at a time when sympathetic is highest and vagal activity lowest.

AB - Background Evidence from a canine experimental acute myocardial infarction (MI) model shows that until the seventh week after MI, the relationship between stellate ganglion nerve activity (SGNA) and vagal nerve activity (VNA) progressively increases. Objective The purpose of this study was to evaluate how autonomic nervous system activity influences temporal myocardial repolarization dispersion at this period. Methods We analyzed autonomic nerve activity as well as QT and RR variability from recordings previously obtained in nine dogs. From a total of 48 short-term ECG segments, 24 recorded before and 24 recorded 7 weeks after experimentally-induced MI, we obtained three indices of temporal myocardial repolarization dispersion: QTe (from Q-wave to T-wave end), QTp (from Q-wave to T-wave peak), and Te (from T-wave peak to T-wave end) variability index (QTeVI, QT pVI, TeVI). We also performed heart rate variability power spectral analysis on the same segments. Results After MI, all the QT variables increased QTeVI (median [interquartile range]) (from-1.76[0.82] to-1.32[0.68]), QTeVI (from-1.90[1.01] to-1.45[0.78]), and T eVI (from-0.72[0.67] to-0.22[1.00]), whereas all RR spectral indices decreased (P <.001 for all). Distinct circadian rhythms in QTeVI (P <.05,) QTpVI (P <.001) and TeVI (P <.05) appeared after MI with circadian variations resembling that of SGNA/VNA. The morning QTpVI and TeVI acrophases approached the SGNA/VNA acrophase. Conversely, the evening QTeVI acrophase coincided with another SGNA/VNA peak. After MI, regression analysis detected a positive relationship between SGNA/VNA and TeVI (R2: 0.077; β: 0.278; p< 0.001). Conclusion Temporal myocardial repolarization dispersion shows a circadian variation after MI reaching its peak at a time when sympathetic is highest and vagal activity lowest.

KW - Myocardial infarction

KW - Sudden cardiac death

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