Myocardial rubidium-82 tissue kinetics assessed by dynamic positron emission tomography as a marker of myocardial cell membrane integrity and viability

Juergen Vom Dahl, Otto Muzik, Edwin R. Wolfe, Christine Allman, Gary Hutchins, Markus Schwaiger

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: Recent reports have demonstrated the clinical use of rubidium- 82 chloride (Rb-82) in combination with positron emission tomography (PET) not only as a tracer of myocardial blood flow but also as a marker of cell membrane integrity using static imaging early and late after tracer injection. The purpose of this study was to compare myocardial Rb-82 kinetics assessed by dynamic PET imaging as a marker for tissue viability with regional fluorine-18 fluorodeoxyglucose (FDG) uptake in patients with coronary artery disease. Methods and Results: Twenty-seven patients with angiographically proven coronary artery disease and 5 subjects with a low likelihood for coronary artery disease underwent dynamic PET imaging under testing conditions using Rb-82 and FDG. Both image sequences served as input data for a semiautomated regional analysis program. This program generated polar maps representing Rb-82 tissue half-life and FDG utilization assessed by Patlak's approach. Myocardial tissue viability was visually determined from static Rb-82 and FDG images. Regions were categorized as normal, ischemically compromised, and scar tissue. Their coordinates were subsequently copied to the functional polar maps for further analyses. In normal subjects, Rb-82 tissue half-life was homogeneous throughout the left ventricle (90±11 seconds). In coronary patients, differences between Rb-82 tissue half-lives in normal and scar tissue were highly significant (95±10 and 57±15 seconds, respectively; P

Original languageEnglish (US)
Pages (from-to)238-245
Number of pages8
JournalCirculation
Volume93
Issue number2
StatePublished - Jan 15 1996
Externally publishedYes

Fingerprint

Rubidium
Positron-Emission Tomography
Cell Survival
Cell Membrane
Coronary Artery Disease
Tissue Survival
Cicatrix
Half-Life
Fluorodeoxyglucose F18
rubidium chloride
Heart Ventricles
Injections

Keywords

  • myocardium
  • perfusion
  • potassium
  • tomography

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Myocardial rubidium-82 tissue kinetics assessed by dynamic positron emission tomography as a marker of myocardial cell membrane integrity and viability. / Vom Dahl, Juergen; Muzik, Otto; Wolfe, Edwin R.; Allman, Christine; Hutchins, Gary; Schwaiger, Markus.

In: Circulation, Vol. 93, No. 2, 15.01.1996, p. 238-245.

Research output: Contribution to journalArticle

Vom Dahl, Juergen ; Muzik, Otto ; Wolfe, Edwin R. ; Allman, Christine ; Hutchins, Gary ; Schwaiger, Markus. / Myocardial rubidium-82 tissue kinetics assessed by dynamic positron emission tomography as a marker of myocardial cell membrane integrity and viability. In: Circulation. 1996 ; Vol. 93, No. 2. pp. 238-245.
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