n-Alkanols potentiate sodium channel inactivation in squid giant axons

G. S. Oxford, R. P. Swenson

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The effects of n-octanol and n-decanol on nerve membrane sodium channels were examined in internally perfused, voltage-clamped squid giant axons. Both n-octanol and n-decanol almost completely eliminated the residual sodium conductance at the end of 8-ms voltage steps. In contrast, peak sodium conductance was only partially reduced. This block of peak and residual sodium conductance was very reversible and seen with both internal and external alkanol application. The differential sensitivity of peak and residual conductance to alkanol treatment was eliminated after internal pronase treatment, suggesting that n-octanol nd n-decanol enhance the normal inactivation mechanism rather than directly blocking channels in a time-dependent manner.

Original languageEnglish (US)
Pages (from-to)585-590
Number of pages6
JournalBiophysical Journal
Volume26
Issue number3
StatePublished - 1979
Externally publishedYes

Fingerprint

1-Octanol
Decapodiformes
Sodium Channels
Axons
Sodium
Delayed Emergence from Anesthesia
Pronase
Ion Channels
n-decyl alcohol

ASJC Scopus subject areas

  • Biophysics

Cite this

Oxford, G. S., & Swenson, R. P. (1979). n-Alkanols potentiate sodium channel inactivation in squid giant axons. Biophysical Journal, 26(3), 585-590.

n-Alkanols potentiate sodium channel inactivation in squid giant axons. / Oxford, G. S.; Swenson, R. P.

In: Biophysical Journal, Vol. 26, No. 3, 1979, p. 585-590.

Research output: Contribution to journalArticle

Oxford, GS & Swenson, RP 1979, 'n-Alkanols potentiate sodium channel inactivation in squid giant axons', Biophysical Journal, vol. 26, no. 3, pp. 585-590.
Oxford, G. S. ; Swenson, R. P. / n-Alkanols potentiate sodium channel inactivation in squid giant axons. In: Biophysical Journal. 1979 ; Vol. 26, No. 3. pp. 585-590.
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