Nabilone: An Effective Antiemetic in Patients Receiving Cancer Chemotherapy

LAWRENCE H. EINHORN, CATHERINE NAGY, BECKY FURNAS, STEPHEN D. WILLIAMS

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Eighty evaluable patients receiving chemotherapy were entered on a random prospective double-blind study to evaluate the effectiveness of nabilone, a synthetic cannabinoid, compared to prochlorperazine. Most of these patients received cisplatin, a drug that universally produces severe nausea and vomiting, as part of a combination chemotherapy regimen. The patients served as their own controls, receiving either nabilone or prochlorperazine during two consecutive treatment courses with the identical chemotherapy. Side effects consisting of hypotension and lethargy were more pronounced with nabilone. Toxicity, in general, did not preclude antiemetic treatment and in no way interfered with chemotherapy. Sixty patients (75 per cent) reported nabilone to be more effective than prochlorperazine for relief of nausea and vomiting. Of these 60 patients, 46 required further chemotherapy and continued taking nabilone as the antiemetic of choice.

Original languageEnglish (US)
Pages (from-to)64S-69S
JournalThe Journal of Clinical Pharmacology
Volume21
Issue number1 S
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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