Nabilone

an effective antiemetic in patients receiving cancer chemotherapy.

Lawrence Einhorn, C. Nagy, B. Furnas, S. D. Williams

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Eighty evaluable patients receiving chemotherapy were entered on a random prospective double-blind study to evaluate the effectiveness of nabilone, a synthetic cannabinoid, compared to prochlorperazine. Most of these patients received cisplatin, a drug that universally produces severe nausea and vomiting, as part of a combination chemotherapy regimen. The patients served as their own controls, receiving either nabilone or prochlorperazine during two consecutive treatment courses with the identical chemotherapy. Side effects consisting of hypotension and lethargy were more pronounced with nabilone. Toxicity, in general, did not preclude antiemetic treatment and in no way interfered with chemotherapy. Sixty patients (75 per cent) reported nabilone to be more effective than prochlorperazine for relief of nausea and vomiting. Of these 60 patients, 46 required further chemotherapy and continued taking nabilone as the antiemetic of choice.

Original languageEnglish
JournalJournal of Clinical Pharmacology
Volume21
Issue number8-9 Suppl
StatePublished - Aug 1981

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Antiemetics
Prochlorperazine
Drug Therapy
Neoplasms
Nausea
Vomiting
Lethargy
Cannabinoids
Combination Drug Therapy
Double-Blind Method
Hypotension
Cisplatin
nabilone
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Nabilone : an effective antiemetic in patients receiving cancer chemotherapy. / Einhorn, Lawrence; Nagy, C.; Furnas, B.; Williams, S. D.

In: Journal of Clinical Pharmacology, Vol. 21, No. 8-9 Suppl, 08.1981.

Research output: Contribution to journalArticle

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