Nanomedicine for treating spinal cord injury

Jacqueline Y. Tyler, Xiao Ming Xu, Ji Xin Cheng

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Spinal cord injury results in significant mortality and morbidity, lifestyle changes, and difficult rehabilitation. Treatment of spinal cord injury is challenging because the spinal cord is both complex to treat acutely and difficult to regenerate. Nanomaterials can be used to provide effective treatments; their unique properties can facilitate drug delivery to the injury site, enact as neuroprotective agents, or provide platforms to stimulate regrowth of damaged tissues. We review recent uses of nanomaterials including nanowires, micelles, nanoparticles, liposomes, and carbon-based nanomaterials for neuroprotection in the acute phase. We also review the design and neural regenerative application of electrospun scaffolds, conduits, and self-assembling peptide scaffolds.

Original languageEnglish (US)
Pages (from-to)8821-8836
Number of pages16
JournalNanoscale
Volume5
Issue number19
DOIs
StatePublished - Oct 7 2013

ASJC Scopus subject areas

  • Materials Science(all)

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