Nanoparticle-based calcium phosphate substrates: Gas phase synthesis and potential applications

Parimal V. Bapat, Rebecca Kraft, Marco C. Bottino, Renato P. Camata

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Emulating the ECM microenvironment of natural tissue and understanding how such an environment affects integrin function is a major goal of regenerative medicine and tissue engineering. In this work we have combined laser and aerosol techniques to create nanoengineered substrates comprising calcium phosphate nanoparticles of well controlled size on atomically flat SiO2 layers. In our process, gas suspended calcium phosphate nanoparticles are generated by ablation of a solid hydroxyapatite target inside a tube furnace at 800-900°C in presence of argon/H2O flow using a KrF excimer laser and deposited on a silicon substrate via electrostatic precipitation. Measurements reveal that our system is capable of synthesizing size selected calcium phosphate nanoparticles and the substrates created exhibit some physical characteristics that are similar to those found in the ECM of bone tissue.

Original languageEnglish (US)
Title of host publicationBiosurfaces and Biointerfaces
Number of pages7
StatePublished - Dec 1 2010
Event2009 MRS Fall Meeting - Boston, MA, United States
Duration: Nov 30 2009Dec 4 2009

Publication series

NameMaterials Research Society Symposium Proceedings
ISSN (Print)0272-9172


Other2009 MRS Fall Meeting
CountryUnited States
CityBoston, MA

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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