Nanoparticle-based calcium phosphate substrates: Gas phase synthesis and potential applications

Parimal V. Bapat, Rebecca Kraft, Marco C. Bottino, Renato P. Camata

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Emulating the ECM microenvironment of natural tissue and understanding how such an environment affects integrin function is a major goal of regenerative medicine and tissue engineering. In this work we have combined laser and aerosol techniques to create nanoengineered substrates comprising calcium phosphate nanoparticles of well controlled size on atomically flat SiO2 layers. In our process, gas suspended calcium phosphate nanoparticles are generated by ablation of a solid hydroxyapatite target inside a tube furnace at 800-900°C in presence of argon/H2O flow using a KrF excimer laser and deposited on a silicon substrate via electrostatic precipitation. Measurements reveal that our system is capable of synthesizing size selected calcium phosphate nanoparticles and the substrates created exhibit some physical characteristics that are similar to those found in the ECM of bone tissue.

Original languageEnglish (US)
Title of host publicationMaterials Research Society Symposium Proceedings
Pages65-71
Number of pages7
Volume1236
StatePublished - 2010
Externally publishedYes
Event2009 MRS Fall Meeting - Boston, MA, United States
Duration: Nov 30 2009Dec 4 2009

Other

Other2009 MRS Fall Meeting
CountryUnited States
CityBoston, MA
Period11/30/0912/4/09

Fingerprint

calcium phosphates
Calcium phosphate
Military electronic countermeasures
Gases
vapor phases
Nanoparticles
nanoparticles
Substrates
synthesis
flat layers
Tissue
Argon
tissue engineering
Excimer lasers
Silicon
Durapatite
Ablation
Aerosols
Hydroxyapatite
medicine

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

Cite this

Bapat, P. V., Kraft, R., Bottino, M. C., & Camata, R. P. (2010). Nanoparticle-based calcium phosphate substrates: Gas phase synthesis and potential applications. In Materials Research Society Symposium Proceedings (Vol. 1236, pp. 65-71)

Nanoparticle-based calcium phosphate substrates : Gas phase synthesis and potential applications. / Bapat, Parimal V.; Kraft, Rebecca; Bottino, Marco C.; Camata, Renato P.

Materials Research Society Symposium Proceedings. Vol. 1236 2010. p. 65-71.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bapat, PV, Kraft, R, Bottino, MC & Camata, RP 2010, Nanoparticle-based calcium phosphate substrates: Gas phase synthesis and potential applications. in Materials Research Society Symposium Proceedings. vol. 1236, pp. 65-71, 2009 MRS Fall Meeting, Boston, MA, United States, 11/30/09.
Bapat PV, Kraft R, Bottino MC, Camata RP. Nanoparticle-based calcium phosphate substrates: Gas phase synthesis and potential applications. In Materials Research Society Symposium Proceedings. Vol. 1236. 2010. p. 65-71
Bapat, Parimal V. ; Kraft, Rebecca ; Bottino, Marco C. ; Camata, Renato P. / Nanoparticle-based calcium phosphate substrates : Gas phase synthesis and potential applications. Materials Research Society Symposium Proceedings. Vol. 1236 2010. pp. 65-71
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