Narrow-band imaging versus white light for the detection of proximal colon serrated lesions: A randomized, controlled trial

Douglas Rex, Ryan Clodfelter, Farrah Rahmani, Hala Fatima, Toyia James-Stevenson, John C. Tang, Hak Kim, Lee McHenry, Charles Kahi, Nicholas Rogers, Debra Helper, Sashidhar V. Sagi, William Kessler, John Wo, Monika Fischer, Paul Y. Kwo

Research output: Contribution to journalArticle

27 Scopus citations


Background The value of narrow-band imaging (NBI) for detecting serrated lesions is unknown. Objective To assess NBI for the detection of proximal colon serrated lesions. Design Randomized, controlled trial. Setting Two academic hospital outpatient units. Patients Eight hundred outpatients 50 years of age and older with intact colons undergoing routine screening, surveillance, or diagnostic examinations. Interventions Randomization to colon inspection in NBI versus white-light colonoscopy. Main Outcome Measurements The number of serrated lesions (sessile serrated polyps plus hyperplastic polyps) proximal to the sigmoid colon. Results The mean inspection times for the whole colon and proximal colon were the same for the NBI and white-light groups. There were 204 proximal colon lesions in the NBI group and 158 in the white light group (P =.085). Detection of conventional adenomas was comparable in the 2 groups. Limitations Lack of blinding, endoscopic estimation of polyp location. Conclusion NBI may increase the detection of proximal colon serrated lesions, but the result in this trial did not reach significance. Additional study of this issue is warranted. (Clinical trial registration number: NCT01572428.)

Original languageEnglish (US)
Pages (from-to)166-171
Number of pages6
JournalGastrointestinal Endoscopy
Issue number1
StatePublished - Jan 1 2016


ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

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