Nasolacrimal outflow drainage anomalies in Down's syndrome

David K. Coats, Kathryn M. Brady McCreery, David A. Plager, Lisa Bohra, Dong Seob Kim, Evelyn A. Paysse

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Purpose: To describe structural abnormalities of the lacrimal drainage system and outcomes after treatment for lacrimal outflow obstruction in children with Down's syndrome. Design: Retrospective comparative interventional case series. Participants: Thirty-eight eyes of 22 consecutive Down's syndrome patients who underwent surgical treatment for nasolacrimal drainage obstruction (mean age, 32 months) and 59 eyes of 44 non-Down's syndrome patients who underwent surgical treatment after 2 years of age. Main Outcome Measures: Resolution of symptoms after surgery and presence of anatomic abnormalities of the lacrimal drainage system other than persistent Hasner's membrane. Results: Among the Down's syndrome eyes, complete or partial resolution was noted in 34 (89%) of 38 eyes; 7 (18%) eyes underwent more than 1 procedure. Twenty-eight (74%) of 38 eyes had anatomic anomalies other than persistent Hasner's membrane; anomalies proximal to the nasolacrimal sac predominated. In comparison, 50 (85%) non-Down's syndrome eyes experienced complete or partial resolution, and 19 (32%) had anatomic abnormalities other than persistent Hasner's membrane; anomalies distal to the nasolacrimal sac predominated. Conclusions: Compared with older non-Down's syndrome patients, nasolacrimal outflow obstruction in Down's syndrome patients is more often complicated by anomalies of the lacrimal drainage system proximal to the lacrimal sac. Despite this, surgery can be similarly successful. Awareness of the possible peculiarities of lacrimal outflow obstruction in Down's syndrome patients may allow better selection and use of available treatment options.

Original languageEnglish (US)
Pages (from-to)1437-1441
Number of pages5
JournalOphthalmology
Volume110
Issue number7
DOIs
StatePublished - Jul 1 2003

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Down Syndrome
Drainage
Tears
Membranes
Nasolacrimal Duct
Therapeutics
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Coats, D. K., Brady McCreery, K. M., Plager, D. A., Bohra, L., Kim, D. S., & Paysse, E. A. (2003). Nasolacrimal outflow drainage anomalies in Down's syndrome. Ophthalmology, 110(7), 1437-1441. https://doi.org/10.1016/S0161-6420(03)00410-X

Nasolacrimal outflow drainage anomalies in Down's syndrome. / Coats, David K.; Brady McCreery, Kathryn M.; Plager, David A.; Bohra, Lisa; Kim, Dong Seob; Paysse, Evelyn A.

In: Ophthalmology, Vol. 110, No. 7, 01.07.2003, p. 1437-1441.

Research output: Contribution to journalArticle

Coats, DK, Brady McCreery, KM, Plager, DA, Bohra, L, Kim, DS & Paysse, EA 2003, 'Nasolacrimal outflow drainage anomalies in Down's syndrome', Ophthalmology, vol. 110, no. 7, pp. 1437-1441. https://doi.org/10.1016/S0161-6420(03)00410-X
Coats DK, Brady McCreery KM, Plager DA, Bohra L, Kim DS, Paysse EA. Nasolacrimal outflow drainage anomalies in Down's syndrome. Ophthalmology. 2003 Jul 1;110(7):1437-1441. https://doi.org/10.1016/S0161-6420(03)00410-X
Coats, David K. ; Brady McCreery, Kathryn M. ; Plager, David A. ; Bohra, Lisa ; Kim, Dong Seob ; Paysse, Evelyn A. / Nasolacrimal outflow drainage anomalies in Down's syndrome. In: Ophthalmology. 2003 ; Vol. 110, No. 7. pp. 1437-1441.
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