Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons

Theodore R. Cummins, Sulayman D. Dib-Hajj, Raimund I. Herzog, Stephen G. Waxman

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

The Nav1.6 voltage-gated sodium channel has been implicated in the generation of resurgent currents in cerebellar Purkinje neurons. Our data show that resurgent sodium currents are produced by some large diameter dorsal root ganglion (DRG) neurons from wild-type mice, but not from Na v1.6-null mice; small DRG neurons do not produce resurgent currents. Many, but not all, DRG neurons transfected with Nav1.6 produce resurgent currents. These results demonstrate for the first time the intrinsic ability of Nav1.6 to produce a resurgent current, and also show that cell background is critical in permitting the generation of these currents.

Original languageEnglish (US)
Pages (from-to)2166-2170
Number of pages5
JournalFEBS Letters
Volume579
Issue number10
DOIs
StatePublished - Apr 11 2005

Keywords

  • Biolistic transfection
  • Sensory neuron
  • Sodium channel
  • Sodium current
  • Subthreshold current

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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