Natural history of urothelial inverted papilloma

Ming Tse Sung, Gregory T. MacLennan, Antonio Lopez-Beltran, Rodolfo Montironi, Liang Cheng

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

BACKGROUND. Inverted urothelial papilloma is an uncommon urothelial neoplasm. Although it is traditionally regarded as a benign tumor, conflicting data on multiplicity, recurrence rate, and association with urothelial carcinoma have left uncertainties concerning its biologic behavior. METHODS. The authors analyzed the clinicopathological characteristics of 75 cases of inverted papilloma in the urinary tract without prior or concurrent urothelial carcinoma to determine its biologic behavior and prognosis, and to correlate these findings with surveillance strategies. RESULTS. These patients ranged in age from 26 to 85 years (mean, 60 years). Of the 46 patients for whom tobacco use history was available, 28 gave a history of smoking. Inverted papillomas were located in the urinary bladder (67 cases), prostatic urethra (4 cases), and ureter (4 cases). The majority of vesical tumors arose from the trigone or near the bladder neck. Common presenting complaints included hematuria, dysuria, and irritative voiding symptoms. In 1 case of vesical inverted papilloma, there was a recurrence. All other patients were free of tumor recurrence or progression during a mean follow-up of 68 months (range, 2-240 months). CONCLUSIONS. Both the extremely low incidence of tumor recurrence (1%) and strikingly favorable prognosis suggest that inverted urothelial papilloma, when diagnosed according to strictly defined criteria, is a benign urothelial neoplasm not related to urothelial carcinoma. Therefore, complete transurethral resection of inverted papilloma is adequate surgical therapy, and surveillance protocols as rigorous as those employed in the management of urothelial carcinoma seem unnecessary.

Original languageEnglish (US)
Pages (from-to)2622-2627
Number of pages6
JournalCancer
Volume107
Issue number11
DOIs
StatePublished - Dec 1 2006

Fingerprint

Inverted Papilloma
Carcinoma
Recurrence
Urinary Bladder
Neoplasms
Dysuria
Tobacco Use
Hematuria
Urethra
Ureter
Urinary Tract
Urinary Bladder Neoplasms
Uncertainty
Smoking
History
Incidence

Keywords

  • Bladder
  • Inverted papilloma
  • Neoplasia
  • Prognosis
  • Urinary tract

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sung, M. T., MacLennan, G. T., Lopez-Beltran, A., Montironi, R., & Cheng, L. (2006). Natural history of urothelial inverted papilloma. Cancer, 107(11), 2622-2627. https://doi.org/10.1002/cncr.22311

Natural history of urothelial inverted papilloma. / Sung, Ming Tse; MacLennan, Gregory T.; Lopez-Beltran, Antonio; Montironi, Rodolfo; Cheng, Liang.

In: Cancer, Vol. 107, No. 11, 01.12.2006, p. 2622-2627.

Research output: Contribution to journalArticle

Sung, MT, MacLennan, GT, Lopez-Beltran, A, Montironi, R & Cheng, L 2006, 'Natural history of urothelial inverted papilloma', Cancer, vol. 107, no. 11, pp. 2622-2627. https://doi.org/10.1002/cncr.22311
Sung MT, MacLennan GT, Lopez-Beltran A, Montironi R, Cheng L. Natural history of urothelial inverted papilloma. Cancer. 2006 Dec 1;107(11):2622-2627. https://doi.org/10.1002/cncr.22311
Sung, Ming Tse ; MacLennan, Gregory T. ; Lopez-Beltran, Antonio ; Montironi, Rodolfo ; Cheng, Liang. / Natural history of urothelial inverted papilloma. In: Cancer. 2006 ; Vol. 107, No. 11. pp. 2622-2627.
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AB - BACKGROUND. Inverted urothelial papilloma is an uncommon urothelial neoplasm. Although it is traditionally regarded as a benign tumor, conflicting data on multiplicity, recurrence rate, and association with urothelial carcinoma have left uncertainties concerning its biologic behavior. METHODS. The authors analyzed the clinicopathological characteristics of 75 cases of inverted papilloma in the urinary tract without prior or concurrent urothelial carcinoma to determine its biologic behavior and prognosis, and to correlate these findings with surveillance strategies. RESULTS. These patients ranged in age from 26 to 85 years (mean, 60 years). Of the 46 patients for whom tobacco use history was available, 28 gave a history of smoking. Inverted papillomas were located in the urinary bladder (67 cases), prostatic urethra (4 cases), and ureter (4 cases). The majority of vesical tumors arose from the trigone or near the bladder neck. Common presenting complaints included hematuria, dysuria, and irritative voiding symptoms. In 1 case of vesical inverted papilloma, there was a recurrence. All other patients were free of tumor recurrence or progression during a mean follow-up of 68 months (range, 2-240 months). CONCLUSIONS. Both the extremely low incidence of tumor recurrence (1%) and strikingly favorable prognosis suggest that inverted urothelial papilloma, when diagnosed according to strictly defined criteria, is a benign urothelial neoplasm not related to urothelial carcinoma. Therefore, complete transurethral resection of inverted papilloma is adequate surgical therapy, and surveillance protocols as rigorous as those employed in the management of urothelial carcinoma seem unnecessary.

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