Natural killer T (NKT) cells and their role in antitumor immunity

Randy Brutkiewicz, Venkataraman Sriram

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Natural killer T (NKT) cells have become a major focus for those who study the innate immune response to tumors and infectious diseases, as well as autoimmunity. These novel T lymphocytes produce both Th1 and Th2 cytokines, recognize phospholipid and glycolipid antigens presented by CD1 molecules in a similar manner as peptides are recognized by cytotoxic T lymphocytes (CTL), and kill tumor cell targets by a perforin-dependent mechanism like NK cells and CTL. These ascribed functions thus demonstrate that NKT cells are a unique cytotoxic effector cell subpopulation with a kaleidoscope of activities. Because they can mediate antitumor effects in vivo with or without the collaboration of NK cells, the study of NKT cells in antitumor immunity may lead to novel treatments based on the ability to manipulate the generation and/or activity of these multifunctional lymphocytes.

Original languageEnglish
Pages (from-to)287-298
Number of pages12
JournalCritical Reviews in Oncology/Hematology
Volume41
Issue number3
DOIs
StatePublished - 2002

Fingerprint

Natural Killer T-Cells
Immunity
Cytotoxic T-Lymphocytes
Natural Killer Cells
CD1 Antigens
Perforin
Glycolipids
Autoimmunity
Innate Immunity
Communicable Diseases
Neoplasms
Phospholipids
Lymphocytes
Cytokines
T-Lymphocytes
Peptides

Keywords

  • Antitumor
  • CD1
  • Cytokines
  • Glycolipids
  • IL-12
  • NKT cells

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Natural killer T (NKT) cells and their role in antitumor immunity. / Brutkiewicz, Randy; Sriram, Venkataraman.

In: Critical Reviews in Oncology/Hematology, Vol. 41, No. 3, 2002, p. 287-298.

Research output: Contribution to journalArticle

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