Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons

Theodore Cummins, Sulayman D. Dib-Hajj, Raimund I. Herzog, Stephen G. Waxman

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

The Nav1.6 voltage-gated sodium channel has been implicated in the generation of resurgent currents in cerebellar Purkinje neurons. Our data show that resurgent sodium currents are produced by some large diameter dorsal root ganglion (DRG) neurons from wild-type mice, but not from Na v1.6-null mice; small DRG neurons do not produce resurgent currents. Many, but not all, DRG neurons transfected with Nav1.6 produce resurgent currents. These results demonstrate for the first time the intrinsic ability of Nav1.6 to produce a resurgent current, and also show that cell background is critical in permitting the generation of these currents.

Original languageEnglish
Pages (from-to)2166-2170
Number of pages5
JournalFEBS Letters
Volume579
Issue number10
DOIs
StatePublished - Apr 11 2005

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Spinal Ganglia
Sensory Receptor Cells
Neurons
Sodium
NAV1.6 Voltage-Gated Sodium Channel
Purkinje Cells

Keywords

  • Biolistic transfection
  • Sensory neuron
  • Sodium channel
  • Sodium current
  • Subthreshold current

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons. / Cummins, Theodore; Dib-Hajj, Sulayman D.; Herzog, Raimund I.; Waxman, Stephen G.

In: FEBS Letters, Vol. 579, No. 10, 11.04.2005, p. 2166-2170.

Research output: Contribution to journalArticle

Cummins, Theodore ; Dib-Hajj, Sulayman D. ; Herzog, Raimund I. ; Waxman, Stephen G. / Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons. In: FEBS Letters. 2005 ; Vol. 579, No. 10. pp. 2166-2170.
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