Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension

Samir K. Gupta, Changyu Shen, Kieren J. Mather, Rajiv Agarwal, Michael P. Dubé

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

It is unknown whether systemic endothelial dysfunction underlies the association between nephropathy and cardiovascular disease (CVD) in persons infected with human immunodeficiency virus (HIV). Spot urine protein to creatinine ratio, spot urine albumin to creatinine ratio, creatinine clearance, estimated glomerular filtration rate, and flow-mediated dilation (FMD) of the brachial artery were evaluated in 123 study participants infected with HIV (58 receiving antiretroviral therapy [ART] and 65 not receiving ART) with no history of diabetes or hypertension. None of the renal markers, modeled as either continuous or categorical variables, correlated with FMD. Contrary to expectations, endothelial dysfunction may not be the link between nephropathy and CVD in HIV.

Original languageEnglish (US)
Pages (from-to)1946-1950
Number of pages5
JournalJournal of Infectious Diseases
Volume204
Issue number12
DOIs
StatePublished - Dec 15 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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