Neointimal hyperplasia following argon ion laser carotid endarterectomy: With and without endothelial cell seeding

Michael G. Wilcox, Alan P. Sawchuk

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background and Objective: This study compares the development of neointimal hyperplasia following conventional and argon ion laser carotid endarterectomy and assesses the potential advantage of endothelial cell seeding. Study Design/Materials and Methods: Eight dogs underwent conventional endarterectomy in one carotid artery and an argon ion laser endarterectomy in the other. After 42 days, these arteries were harvested and the intimal thicknesses were compared. Six additional dogs underwent bilateral argon ion laser carotid endarterectomy with endothelial cell seeding on one side only. These arteries were harvested after 65 days and their mean intimal thicknesses were compared. Results: At 42 days, the mean intimal thickness in the conventional endarterectomy group was 0.070±0.007 mm; in the argon ion laser endarterectomy group it was 0.058±0.001 mm (P=0.76, NS). At 65 days, the mean intimal thickness in the group without endothelial cell seeding was 0.125±0.003 mm vs. 0.061±0.001 mm on the seeded side (P=0.043). Conclusion: Argon ion laser carotid endarterectomy results in no more neointimal hyperplasia than conventional endarterectomy. The neointimal hyperplasia is reduced by endothelial cell seeding.

Original languageEnglish (US)
Pages (from-to)367-372
Number of pages6
JournalLasers in Surgery and Medicine
Volume20
Issue number4
DOIs
StatePublished - May 13 1997

Keywords

  • argon ion laser
  • carotid endarterectomy
  • endothelial cell seeding
  • laser endarterectomy
  • neointimal hyperplasia

ASJC Scopus subject areas

  • Surgery

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