Neonatal apnea, xanthines, and necrotizing enterocolitis

Jay L. Grosfeld, Michael Dalsing, Meredith Hull, Thomas R. Weber

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

This study evaluates the relationship of xanthinetreatment of premature apnea and NEC in a bowel ischemia model. The superior mesenteric artery was occluded for 1.0 minute in 82 wheanling rats. Group I (n=41) were untreated controls. Group II (n=21) received aminophylline (AMPH) 40 mg/kg I.P., 4 hr and immediately prior to clamping. Animals were evaluated for bowel infarction, perforation, and mortality at 7 days. In 20 additional rats (10 @ group) bowel was evaluated by scanning electron microscopy (EM) at timed intervals (5 and 30 min). Ischemic bowel occurred in 25 of 41 (60%) controls (18 (43%) with necrosis; 7 (17%) with perforations) and 19 of 21 (90%) rats with AMPH (15 (70%) and had necrosis; 4 (19%) perforations). Mortality was 60% (controls) and 90% (AMPH) respectively (p<.05). On EM, AMPH enhanced bacterial overgrowth however actual mucosal damage appeared similar. Following ischemia, AMPH has an adverse effect on the bowel. Use of AMPH in prematures at risk for NEC is questioned.

Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalJournal of Pediatric Surgery
Volume18
Issue number1
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Xanthines
Aminophylline
Necrotizing Enterocolitis
Apnea
Necrosis
Ischemia
Superior Mesenteric Artery
Mortality
Constriction
Electron Scanning Microscopy
Infarction
Electron Microscopy

Keywords

  • aminophylline
  • necrotizing enterocolitis
  • Neonatal apnea

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Neonatal apnea, xanthines, and necrotizing enterocolitis. / Grosfeld, Jay L.; Dalsing, Michael; Hull, Meredith; Weber, Thomas R.

In: Journal of Pediatric Surgery, Vol. 18, No. 1, 1983, p. 80-84.

Research output: Contribution to journalArticle

Grosfeld, Jay L. ; Dalsing, Michael ; Hull, Meredith ; Weber, Thomas R. / Neonatal apnea, xanthines, and necrotizing enterocolitis. In: Journal of Pediatric Surgery. 1983 ; Vol. 18, No. 1. pp. 80-84.
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