Neonatal arterial ischemic stroke and cerebral sinovenous thrombosis are more commonly diagnosed in boys

Meredith Golomb, Paul T. Dick, Daune L. MacGregor, Rosalind Curtis, Marianne Sofronas, Gabrielle A. deVeber

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The risk factors for arterial ischemic stroke and cerebral sinovenous thrombosis in neonates are not well understood. We looked at gender, birthweight, and gestational age in neonates with arterial ischemic stroke and cerebral sinovenous thrombosis to see if there were trends suggesting that these were risk factors. We identified neonates with a gestational age at birth ≥ 36 weeks and a diagnosis of arterial ischemic stroke or cerebral sinovenous thrombosis made by computed tomography or magnetic resonance imaging during the neonatal period from a consecutive cohort study of children with arterial ischemic stroke and cerebral sinovenous thrombosis in Ontario. Data on gender, birthweight, and gestational age were obtained by health record review. Sixty-six children with neonatal arterial ischemic stroke were identified. Forty-one (62.1%; 95% CI 49.3-73.8%) were male. Thirty-two children with neonatal cerebral sinovenous thrombosis were identified. Twenty-five (78.1%; 95% CI 60.0-90.7%) were male. One male child was identified with both arterial ischemic stroke and cerebral sinovenous thrombosis. There was a trend toward higher than average birthweights among neonates with arterial ischemic stroke and a trend toward older gestational age in female neonates with arterial ischemic stroke. Our data suggest that neonatal arterial ischemic stroke and cerebral sinovenous thrombosis are more commonly diagnosed in boys. The slightly larger size of male neonates may be contributory in arterial ischemic stroke. It is not known whether boys are at higher risk of developing arterial ischemic stroke and cerebral sinoven thrombosis or are simply more likely to present with symptoms resulting in diagnosis. These issues need further study.

Original languageEnglish
Pages (from-to)493-497
Number of pages5
JournalJournal of Child Neurology
Volume19
Issue number7
StatePublished - Jul 2004

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Intracranial Thrombosis
Stroke
Newborn Infant
Gestational Age
Ontario
Cohort Studies
Tomography
Magnetic Resonance Imaging
Parturition

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Golomb, M., Dick, P. T., MacGregor, D. L., Curtis, R., Sofronas, M., & deVeber, G. A. (2004). Neonatal arterial ischemic stroke and cerebral sinovenous thrombosis are more commonly diagnosed in boys. Journal of Child Neurology, 19(7), 493-497.

Neonatal arterial ischemic stroke and cerebral sinovenous thrombosis are more commonly diagnosed in boys. / Golomb, Meredith; Dick, Paul T.; MacGregor, Daune L.; Curtis, Rosalind; Sofronas, Marianne; deVeber, Gabrielle A.

In: Journal of Child Neurology, Vol. 19, No. 7, 07.2004, p. 493-497.

Research output: Contribution to journalArticle

Golomb, M, Dick, PT, MacGregor, DL, Curtis, R, Sofronas, M & deVeber, GA 2004, 'Neonatal arterial ischemic stroke and cerebral sinovenous thrombosis are more commonly diagnosed in boys', Journal of Child Neurology, vol. 19, no. 7, pp. 493-497.
Golomb, Meredith ; Dick, Paul T. ; MacGregor, Daune L. ; Curtis, Rosalind ; Sofronas, Marianne ; deVeber, Gabrielle A. / Neonatal arterial ischemic stroke and cerebral sinovenous thrombosis are more commonly diagnosed in boys. In: Journal of Child Neurology. 2004 ; Vol. 19, No. 7. pp. 493-497.
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