Neonatal neutrophils

The good, the bad, and the ugly

Joyce M. Koenig, Mervin Yoder

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Neonates have age-specific quantitative and qualitative impairments in neutrophil function that are more pronounced in newborns delivered prematurely. The diminished capacity of neonatal neutrophils to respond to stimulation and their intrinsic longevity may be characteristics that provide a host defense and survival advantage. However, neutrophil dysfunction is one aspect of innate immunity that places the newborn population at risk for the morbidity and mortality associated with invasive bacterial and fungal infections and increases their propensity to develop chronic inflammatory disorders. Studies to define the mechanisms underlying neonatal neutrophil dysfunction may prove useful in dissecting the regulatory pathways used by neutrophils in general. Such information will be critical to the development of targeted therapies for the management of infections and chronic inflammatory disorders in all age groups.

Original languageEnglish
Pages (from-to)39-51
Number of pages13
JournalClinics in Perinatology
Volume31
Issue number1
DOIs
StatePublished - Mar 2004

Fingerprint

Neutrophils
Newborn Infant
Bacterial Infections
Innate Immunity
Age Groups
Morbidity
Survival
Mortality
Infection
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Neonatal neutrophils : The good, the bad, and the ugly. / Koenig, Joyce M.; Yoder, Mervin.

In: Clinics in Perinatology, Vol. 31, No. 1, 03.2004, p. 39-51.

Research output: Contribution to journalArticle

@article{9305e52b90fa4889bdacdb28eefe326f,
title = "Neonatal neutrophils: The good, the bad, and the ugly",
abstract = "Neonates have age-specific quantitative and qualitative impairments in neutrophil function that are more pronounced in newborns delivered prematurely. The diminished capacity of neonatal neutrophils to respond to stimulation and their intrinsic longevity may be characteristics that provide a host defense and survival advantage. However, neutrophil dysfunction is one aspect of innate immunity that places the newborn population at risk for the morbidity and mortality associated with invasive bacterial and fungal infections and increases their propensity to develop chronic inflammatory disorders. Studies to define the mechanisms underlying neonatal neutrophil dysfunction may prove useful in dissecting the regulatory pathways used by neutrophils in general. Such information will be critical to the development of targeted therapies for the management of infections and chronic inflammatory disorders in all age groups.",
author = "Koenig, {Joyce M.} and Mervin Yoder",
year = "2004",
month = "3",
doi = "10.1016/j.clp.2004.03.013",
language = "English",
volume = "31",
pages = "39--51",
journal = "Clinics in Perinatology",
issn = "0095-5108",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Neonatal neutrophils

T2 - The good, the bad, and the ugly

AU - Koenig, Joyce M.

AU - Yoder, Mervin

PY - 2004/3

Y1 - 2004/3

N2 - Neonates have age-specific quantitative and qualitative impairments in neutrophil function that are more pronounced in newborns delivered prematurely. The diminished capacity of neonatal neutrophils to respond to stimulation and their intrinsic longevity may be characteristics that provide a host defense and survival advantage. However, neutrophil dysfunction is one aspect of innate immunity that places the newborn population at risk for the morbidity and mortality associated with invasive bacterial and fungal infections and increases their propensity to develop chronic inflammatory disorders. Studies to define the mechanisms underlying neonatal neutrophil dysfunction may prove useful in dissecting the regulatory pathways used by neutrophils in general. Such information will be critical to the development of targeted therapies for the management of infections and chronic inflammatory disorders in all age groups.

AB - Neonates have age-specific quantitative and qualitative impairments in neutrophil function that are more pronounced in newborns delivered prematurely. The diminished capacity of neonatal neutrophils to respond to stimulation and their intrinsic longevity may be characteristics that provide a host defense and survival advantage. However, neutrophil dysfunction is one aspect of innate immunity that places the newborn population at risk for the morbidity and mortality associated with invasive bacterial and fungal infections and increases their propensity to develop chronic inflammatory disorders. Studies to define the mechanisms underlying neonatal neutrophil dysfunction may prove useful in dissecting the regulatory pathways used by neutrophils in general. Such information will be critical to the development of targeted therapies for the management of infections and chronic inflammatory disorders in all age groups.

UR - http://www.scopus.com/inward/record.url?scp=2942530745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942530745&partnerID=8YFLogxK

U2 - 10.1016/j.clp.2004.03.013

DO - 10.1016/j.clp.2004.03.013

M3 - Article

VL - 31

SP - 39

EP - 51

JO - Clinics in Perinatology

JF - Clinics in Perinatology

SN - 0095-5108

IS - 1

ER -