Neonatal outcomes with different betamethasone dosing regimens: A comparison

David Haas, William McCullough, Cara H. Olsen, Daniel T. Shiau, John Richard, Emory A. Fry, Michael F. McNamara

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

OBJECTIVE: To determine any differences in neonatal outcomes when dosing betamethasone every 12 hours vs. 24 hours for anticipated preterm delivery. STUDY DESIGN: A retrospective review of births at <36 weeks' gestation from January 1, 1996, to July 1, 2000. Maternal and neonatal charts were reviewed. The deliveries were separated into 3 groups: those not receiving antenatal corticosteroids, those who received betamethasone 12 hours apart and those who received 24-hour dosing. Demographic, obstetric and neonatal variables were compared between the groups. RESULTS: There were 909 deliveries analyzed. With the 2 betamethasone groups, a significant difference was found for more maternal antibiotic use (90.4% s. 83.6%, p = 0.03), venous cord blood gas pH (7.31 vs. 7.32, p = 0.04) and neonatal surfactant use (39.8% vs. 25.5%, p = 0.001) in the 12-hour group as compared to the 24-hour group. For all other outcomes there was no difference. CONCLUSION: Outcomes using a 12-hour dosing schedule of betamethasone were similar to those using a 24-hour regimen in this retrospective review. Twelve-hour dosing could be considered an alternative way to deliver antenatal corticosteroids.

Original languageEnglish (US)
Pages (from-to)915-922
Number of pages8
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume50
Issue number12
StatePublished - Dec 2005
Externally publishedYes

Fingerprint

Betamethasone
Adrenal Cortex Hormones
Mothers
Fetal Blood
Surface-Active Agents
Obstetrics
Appointments and Schedules
Gases
Demography
Parturition
Anti-Bacterial Agents
Pregnancy

Keywords

  • Betamethasone
  • Neonate
  • Pregnancy outcomes

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Haas, D., McCullough, W., Olsen, C. H., Shiau, D. T., Richard, J., Fry, E. A., & McNamara, M. F. (2005). Neonatal outcomes with different betamethasone dosing regimens: A comparison. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 50(12), 915-922.

Neonatal outcomes with different betamethasone dosing regimens : A comparison. / Haas, David; McCullough, William; Olsen, Cara H.; Shiau, Daniel T.; Richard, John; Fry, Emory A.; McNamara, Michael F.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 50, No. 12, 12.2005, p. 915-922.

Research output: Contribution to journalArticle

Haas, D, McCullough, W, Olsen, CH, Shiau, DT, Richard, J, Fry, EA & McNamara, MF 2005, 'Neonatal outcomes with different betamethasone dosing regimens: A comparison', Journal of Reproductive Medicine for the Obstetrician and Gynecologist, vol. 50, no. 12, pp. 915-922.
Haas, David ; McCullough, William ; Olsen, Cara H. ; Shiau, Daniel T. ; Richard, John ; Fry, Emory A. ; McNamara, Michael F. / Neonatal outcomes with different betamethasone dosing regimens : A comparison. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 2005 ; Vol. 50, No. 12. pp. 915-922.
@article{1aa605620ce045a79ae1ebf397ac876d,
title = "Neonatal outcomes with different betamethasone dosing regimens: A comparison",
abstract = "OBJECTIVE: To determine any differences in neonatal outcomes when dosing betamethasone every 12 hours vs. 24 hours for anticipated preterm delivery. STUDY DESIGN: A retrospective review of births at <36 weeks' gestation from January 1, 1996, to July 1, 2000. Maternal and neonatal charts were reviewed. The deliveries were separated into 3 groups: those not receiving antenatal corticosteroids, those who received betamethasone 12 hours apart and those who received 24-hour dosing. Demographic, obstetric and neonatal variables were compared between the groups. RESULTS: There were 909 deliveries analyzed. With the 2 betamethasone groups, a significant difference was found for more maternal antibiotic use (90.4{\%} s. 83.6{\%}, p = 0.03), venous cord blood gas pH (7.31 vs. 7.32, p = 0.04) and neonatal surfactant use (39.8{\%} vs. 25.5{\%}, p = 0.001) in the 12-hour group as compared to the 24-hour group. For all other outcomes there was no difference. CONCLUSION: Outcomes using a 12-hour dosing schedule of betamethasone were similar to those using a 24-hour regimen in this retrospective review. Twelve-hour dosing could be considered an alternative way to deliver antenatal corticosteroids.",
keywords = "Betamethasone, Neonate, Pregnancy outcomes",
author = "David Haas and William McCullough and Olsen, {Cara H.} and Shiau, {Daniel T.} and John Richard and Fry, {Emory A.} and McNamara, {Michael F.}",
year = "2005",
month = "12",
language = "English (US)",
volume = "50",
pages = "915--922",
journal = "The Journal of reproductive medicine",
issn = "0024-7758",
publisher = "Donna Kessel",
number = "12",

}

TY - JOUR

T1 - Neonatal outcomes with different betamethasone dosing regimens

T2 - A comparison

AU - Haas, David

AU - McCullough, William

AU - Olsen, Cara H.

AU - Shiau, Daniel T.

AU - Richard, John

AU - Fry, Emory A.

AU - McNamara, Michael F.

PY - 2005/12

Y1 - 2005/12

N2 - OBJECTIVE: To determine any differences in neonatal outcomes when dosing betamethasone every 12 hours vs. 24 hours for anticipated preterm delivery. STUDY DESIGN: A retrospective review of births at <36 weeks' gestation from January 1, 1996, to July 1, 2000. Maternal and neonatal charts were reviewed. The deliveries were separated into 3 groups: those not receiving antenatal corticosteroids, those who received betamethasone 12 hours apart and those who received 24-hour dosing. Demographic, obstetric and neonatal variables were compared between the groups. RESULTS: There were 909 deliveries analyzed. With the 2 betamethasone groups, a significant difference was found for more maternal antibiotic use (90.4% s. 83.6%, p = 0.03), venous cord blood gas pH (7.31 vs. 7.32, p = 0.04) and neonatal surfactant use (39.8% vs. 25.5%, p = 0.001) in the 12-hour group as compared to the 24-hour group. For all other outcomes there was no difference. CONCLUSION: Outcomes using a 12-hour dosing schedule of betamethasone were similar to those using a 24-hour regimen in this retrospective review. Twelve-hour dosing could be considered an alternative way to deliver antenatal corticosteroids.

AB - OBJECTIVE: To determine any differences in neonatal outcomes when dosing betamethasone every 12 hours vs. 24 hours for anticipated preterm delivery. STUDY DESIGN: A retrospective review of births at <36 weeks' gestation from January 1, 1996, to July 1, 2000. Maternal and neonatal charts were reviewed. The deliveries were separated into 3 groups: those not receiving antenatal corticosteroids, those who received betamethasone 12 hours apart and those who received 24-hour dosing. Demographic, obstetric and neonatal variables were compared between the groups. RESULTS: There were 909 deliveries analyzed. With the 2 betamethasone groups, a significant difference was found for more maternal antibiotic use (90.4% s. 83.6%, p = 0.03), venous cord blood gas pH (7.31 vs. 7.32, p = 0.04) and neonatal surfactant use (39.8% vs. 25.5%, p = 0.001) in the 12-hour group as compared to the 24-hour group. For all other outcomes there was no difference. CONCLUSION: Outcomes using a 12-hour dosing schedule of betamethasone were similar to those using a 24-hour regimen in this retrospective review. Twelve-hour dosing could be considered an alternative way to deliver antenatal corticosteroids.

KW - Betamethasone

KW - Neonate

KW - Pregnancy outcomes

UR - http://www.scopus.com/inward/record.url?scp=29744438184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29744438184&partnerID=8YFLogxK

M3 - Article

C2 - 16444891

AN - SCOPUS:29744438184

VL - 50

SP - 915

EP - 922

JO - The Journal of reproductive medicine

JF - The Journal of reproductive medicine

SN - 0024-7758

IS - 12

ER -