Neoplastic transformation in tissues of rats exposed to monocrotaline or dehydroretronecine

R. C. Shumaker, K. A. Robertson, I. C. Hsu, J. R. Allen

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Male Sprague-Dawley rats received sc injections biweekly of either the pyrrolizidine alkaloid monocrotaline or its metabolite dehydroretronecine for 1 year. The animals were then observed for an additional 12 months for the induction of neoplasms. Of 60 rats that received dehydroretronecine, 39 developed rhabdomyosarcomas at the injection site, and 5 of these neoplasms metastasized. In the 60 monocrotaline-treated rats, 31 widely dispersed tumors of various cell types were recorded. The reason suggested for the variation in tissue response was that the metabolite dehydroretronecine is a proximate carcinogen, whereas monocrotaline must first be metabolized before its carcinogenic potential is realized.

Original languageEnglish (US)
Pages (from-to)787-790
Number of pages4
JournalJournal of the National Cancer Institute
Volume56
Issue number4
DOIs
StatePublished - Apr 1976
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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