Neovascularisation is a prognostic factor of early recurrence in T1/G2 urothelial bladder tumours

L. Santos, C. Costa, S. Pereira, M. Koch, T. Amaro, F. Cardoso, T. Guimarães, M. J. Bento, F. Lobo, S. Pinto, C. Lopes

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Background: Of patients with superficial bladder cancer, a group are still at risk of disease recurrence, progression and death from their cancer after curative treatment. Angiogenesis is a crucial pathogenic mechanism for this type of urothelial cell carcinoma (UCC), and is a potential therapeutic target. However, the selection of the appropriate patients remains a dilemma. Patients and methods: Vascular endothelial growth factor (VEGF) expression and the presence of angiogenesis and occurrence of CD31, CD34, endoglin and factor VIII immunoexpression, were evaluated in 66 superficial papillary UCCs of the bladder and were correlated with classical histopathological factors and disease outcome. Results: VEGF immunoreactivity was observed in 100% of cases, and more intensely in the luminal surface. The presence of microvessel clusters independently of a fibrovascular core was observed in 22.7% of cases. Of these, the T1/G2 subgroup had an independent and significantly lower recurrence-free survival (P = 0.0002). Conclusions: These results indicate that the presence of angiogenesis in tumour urothelium is a potential prognostic factor in superficial UCC, particularly in T1/G2 tumours, and may be used to select patients for anti-angiogenic treatments.

Original languageEnglish (US)
Pages (from-to)1419-1424
Number of pages6
JournalAnnals of Oncology
Volume14
Issue number9
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

Keywords

  • Angiogenesis
  • Bladder cancer
  • Prognosis
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Hematology
  • Oncology

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    Santos, L., Costa, C., Pereira, S., Koch, M., Amaro, T., Cardoso, F., Guimarães, T., Bento, M. J., Lobo, F., Pinto, S., & Lopes, C. (2003). Neovascularisation is a prognostic factor of early recurrence in T1/G2 urothelial bladder tumours. Annals of Oncology, 14(9), 1419-1424. https://doi.org/10.1093/annonc/mdg377