Nephroblastoma-like tumors in patients with testicular germ cell tumors

Helen Michael, Meredith T. Hull, Richard Foster, Christopher J. Sweeney, Thomas Ulbright

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Nephroblastoma-like tumors (NLTs) developed in metastatic sites in nine men with testicular germ cell tumors (GCTs). These tumors had a characteristic 'triphasic' admixture of primitive tubular structures, sometimes with a glomeruloid pattern, blastema and stroma. Skeletal muscle differentiation was apparent in two cases. Specific neuroendocrine markers (synaptophysin and chromogranin A) were negative. All patients were treated by surgical excision. Six patients were alive with no evidence of disease from 4 to 12 years after diagnosis of GCT and NLT. One patient was alive with disease 6 years after diagnosis of GCT and 3 years after diagnosis of dermal tumor (PNET) had short survival, and one patient died of postoperative infection. We conclude that patients with testicular GCTs in whom NLTs develop in metastatic sites often experience prolonged survival arising in metastatic testicular GCT in most patients. It is important to distinguish NLTs from PNETs in metastatic GCTs because of the more aggressive course and the frequently fatal outcome of the latter.

Original languageEnglish
Pages (from-to)1107-1114
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume22
Issue number9
DOIs
StatePublished - Sep 1998

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Wilms Tumor
Germ Cell and Embryonal Neoplasms
Primitive Neuroectodermal Tumors
Neoplasms
Chromogranin A
Synaptophysin
Fatal Outcome
Survival
Testicular Germ Cell Tumor
Skeletal Muscle
Skin
Infection

Keywords

  • Germ cell tumors
  • Nephroblastoma
  • Testis
  • Wilms' tumor

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Nephroblastoma-like tumors in patients with testicular germ cell tumors. / Michael, Helen; Hull, Meredith T.; Foster, Richard; Sweeney, Christopher J.; Ulbright, Thomas.

In: American Journal of Surgical Pathology, Vol. 22, No. 9, 09.1998, p. 1107-1114.

Research output: Contribution to journalArticle

Michael, Helen ; Hull, Meredith T. ; Foster, Richard ; Sweeney, Christopher J. ; Ulbright, Thomas. / Nephroblastoma-like tumors in patients with testicular germ cell tumors. In: American Journal of Surgical Pathology. 1998 ; Vol. 22, No. 9. pp. 1107-1114.
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