Nephrology-specific issues in women's health osteoporosis in end-stage renal disease

Jill S. Lindberg, Sharon M. Moe

Research output: Contribution to journalArticle

102 Scopus citations


Maintaining the intricate bone mineral homeostasis in patients with chronic renal failure and renal osteodystrophy is a complex and challenging process. In addition to the well described high-turnover bone disease caused by secondary hyperparathyroidism and low-turnover disease in the form of osteomalacia (either from aluminum or a dynamic bone disease) osteopenia also is present in end-stage renal disease patients. In contrast to abnormalities in the ability of bone to remodel, osteopenia is a deficiency in bone mass or volume. The prevalence of fractures in dialysis patients, regardless of histomorphometry appears to exceed that observed in elderly women. This osteopenia that occurs in chronic renal failure patients secondary to multiple factors that include hypogonadism, medications (such as corticosteroids), immobilization, and the typical osteopenia associated with aging. All of these factors amplify the risk of fracture in dialysis patients.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalSeminars in Nephrology
Issue number2
StatePublished - Dec 1 1999

ASJC Scopus subject areas

  • Nephrology

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