Nerve-sparing retroperitoneal lymphadenectomy with preservation of ejaculation

J. P. Donohue, R. S. Foster, R. G. Rowland, R. Bihrle, J. Jones, G. Geier

Research output: Contribution to journalArticle

228 Citations (Scopus)

Abstract

The feasibility of sparing postganglionic fibers of lumbar sympathetic nerves during the course of retroperitoneal lymphadenectomy has been investigated at our university medical center beginning in 1978. We selected 75 patients for nerve-sparing retroperitoneal lymphadenectomy in an effort to preserve ejaculatory function postoperatively. This cohort of patients was selected on the bases of clinical stage. Of the 75 patients 73 had clinical stage I disease. However, 14 of these 73 patients had pathological stage II cancer. No patient was treated with adjuvant chemotherapy after nerve-sparing retroperitoneal lymphadenectomy. Of these 14 patients with pathological stage II disease 4 had relapse: 1 with proved retroperitoneal recurrence, and 3 with serological elevations of tumor markers and questionable clinical findings as to anatomical site of relapse. All 4 patients are free of disease after chemotherapy and/or surgical (1) rescue. There were no local recurrences in the 61 patients with negative nodes. All 75 patients ejaculate and had no evidence of disease more than 2 years after nerve-sparing retroperitoneal lymphadenectomy. It is clear that nerve-sparing retroperitoneal lymphadenectomy is a feasible technique. As noted, it can even be applied to selected patients with low volume positive nodes, yet maintaining relapse and survival figures that are acceptable. Ejaculation is reliably preserved when this nerve-sparing technique is applied accurately in retroperitoneal lymphadenectomy.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalJournal of Urology
Volume144
Issue number2 I
DOIs
StatePublished - Jan 1 1990

Fingerprint

Ejaculation
Lymph Node Excision
Recurrence
Postganglionic Sympathetic Fibers
Adjuvant Chemotherapy
Tumor Biomarkers
Drug Therapy

ASJC Scopus subject areas

  • Urology

Cite this

Nerve-sparing retroperitoneal lymphadenectomy with preservation of ejaculation. / Donohue, J. P.; Foster, R. S.; Rowland, R. G.; Bihrle, R.; Jones, J.; Geier, G.

In: Journal of Urology, Vol. 144, No. 2 I, 01.01.1990, p. 287-291.

Research output: Contribution to journalArticle

Donohue, J. P. ; Foster, R. S. ; Rowland, R. G. ; Bihrle, R. ; Jones, J. ; Geier, G. / Nerve-sparing retroperitoneal lymphadenectomy with preservation of ejaculation. In: Journal of Urology. 1990 ; Vol. 144, No. 2 I. pp. 287-291.
@article{aa1f9c7c062a4f0d93900edcb9ab805b,
title = "Nerve-sparing retroperitoneal lymphadenectomy with preservation of ejaculation",
abstract = "The feasibility of sparing postganglionic fibers of lumbar sympathetic nerves during the course of retroperitoneal lymphadenectomy has been investigated at our university medical center beginning in 1978. We selected 75 patients for nerve-sparing retroperitoneal lymphadenectomy in an effort to preserve ejaculatory function postoperatively. This cohort of patients was selected on the bases of clinical stage. Of the 75 patients 73 had clinical stage I disease. However, 14 of these 73 patients had pathological stage II cancer. No patient was treated with adjuvant chemotherapy after nerve-sparing retroperitoneal lymphadenectomy. Of these 14 patients with pathological stage II disease 4 had relapse: 1 with proved retroperitoneal recurrence, and 3 with serological elevations of tumor markers and questionable clinical findings as to anatomical site of relapse. All 4 patients are free of disease after chemotherapy and/or surgical (1) rescue. There were no local recurrences in the 61 patients with negative nodes. All 75 patients ejaculate and had no evidence of disease more than 2 years after nerve-sparing retroperitoneal lymphadenectomy. It is clear that nerve-sparing retroperitoneal lymphadenectomy is a feasible technique. As noted, it can even be applied to selected patients with low volume positive nodes, yet maintaining relapse and survival figures that are acceptable. Ejaculation is reliably preserved when this nerve-sparing technique is applied accurately in retroperitoneal lymphadenectomy.",
author = "Donohue, {J. P.} and Foster, {R. S.} and Rowland, {R. G.} and R. Bihrle and J. Jones and G. Geier",
year = "1990",
month = "1",
day = "1",
doi = "10.1016/S0022-5347(17)39434-X",
language = "English (US)",
volume = "144",
pages = "287--291",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "2 I",

}

TY - JOUR

T1 - Nerve-sparing retroperitoneal lymphadenectomy with preservation of ejaculation

AU - Donohue, J. P.

AU - Foster, R. S.

AU - Rowland, R. G.

AU - Bihrle, R.

AU - Jones, J.

AU - Geier, G.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The feasibility of sparing postganglionic fibers of lumbar sympathetic nerves during the course of retroperitoneal lymphadenectomy has been investigated at our university medical center beginning in 1978. We selected 75 patients for nerve-sparing retroperitoneal lymphadenectomy in an effort to preserve ejaculatory function postoperatively. This cohort of patients was selected on the bases of clinical stage. Of the 75 patients 73 had clinical stage I disease. However, 14 of these 73 patients had pathological stage II cancer. No patient was treated with adjuvant chemotherapy after nerve-sparing retroperitoneal lymphadenectomy. Of these 14 patients with pathological stage II disease 4 had relapse: 1 with proved retroperitoneal recurrence, and 3 with serological elevations of tumor markers and questionable clinical findings as to anatomical site of relapse. All 4 patients are free of disease after chemotherapy and/or surgical (1) rescue. There were no local recurrences in the 61 patients with negative nodes. All 75 patients ejaculate and had no evidence of disease more than 2 years after nerve-sparing retroperitoneal lymphadenectomy. It is clear that nerve-sparing retroperitoneal lymphadenectomy is a feasible technique. As noted, it can even be applied to selected patients with low volume positive nodes, yet maintaining relapse and survival figures that are acceptable. Ejaculation is reliably preserved when this nerve-sparing technique is applied accurately in retroperitoneal lymphadenectomy.

AB - The feasibility of sparing postganglionic fibers of lumbar sympathetic nerves during the course of retroperitoneal lymphadenectomy has been investigated at our university medical center beginning in 1978. We selected 75 patients for nerve-sparing retroperitoneal lymphadenectomy in an effort to preserve ejaculatory function postoperatively. This cohort of patients was selected on the bases of clinical stage. Of the 75 patients 73 had clinical stage I disease. However, 14 of these 73 patients had pathological stage II cancer. No patient was treated with adjuvant chemotherapy after nerve-sparing retroperitoneal lymphadenectomy. Of these 14 patients with pathological stage II disease 4 had relapse: 1 with proved retroperitoneal recurrence, and 3 with serological elevations of tumor markers and questionable clinical findings as to anatomical site of relapse. All 4 patients are free of disease after chemotherapy and/or surgical (1) rescue. There were no local recurrences in the 61 patients with negative nodes. All 75 patients ejaculate and had no evidence of disease more than 2 years after nerve-sparing retroperitoneal lymphadenectomy. It is clear that nerve-sparing retroperitoneal lymphadenectomy is a feasible technique. As noted, it can even be applied to selected patients with low volume positive nodes, yet maintaining relapse and survival figures that are acceptable. Ejaculation is reliably preserved when this nerve-sparing technique is applied accurately in retroperitoneal lymphadenectomy.

UR - http://www.scopus.com/inward/record.url?scp=0025061423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025061423&partnerID=8YFLogxK

U2 - 10.1016/S0022-5347(17)39434-X

DO - 10.1016/S0022-5347(17)39434-X

M3 - Article

C2 - 2165181

AN - SCOPUS:0025061423

VL - 144

SP - 287

EP - 291

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 2 I

ER -