Nerve sprouting and sudden cardiac death

Ji Min Cao, Lan Chen, Bruce H. KenKnight, Toshihiko Ohara, Moon Hyoung Lee, Jerome Tsai, William W. Lai, Hrayr S. Karagueuzian, Paul L. Wolf, Michael C. Fishbein, Peng-Sheng Chen

Research output: Contribution to journalArticle

313 Citations (Scopus)

Abstract

The factors that contribute to the occurrence of sudden cardiac death (SCD) in patients with chronic myocardial infarction (MI) are not entirely clear. The present study tests the hypothesis that augmented sympathetic nerve regeneration (nerve sprouting) increases the probability of ventricular tachycardia (VT), ventricular fibrillation (VF), and SCD in chronic MI. In dogs with MI and complete atrioventricular (AV) block, we induced cardiac sympathetic nerve sprouting by infusing nerve growth factor (NGF) to the left stellate ganglion (experimental group, n=9). Another 6 dogs with MI and complete AV block but without NGF infusion served as controls (n=6). Immunocytochemical staining revealed a greater magnitude of sympathetic nerve sprouting in the experimental group than in the control group. After MI, all dogs showed spontaneous VT that persisted for 5.8±2.0 days (phase 1 VT). Spontaneous VT reappeared 13.1±6.0 days after surgery (phase 2 VT). The frequency of phase 2 VT was 10-fold higher in the experimental group (2.0±2.0/d) than in the control group (0.2±0.2/d, P

Original languageEnglish (US)
Pages (from-to)816-821
Number of pages6
JournalCirculation Research
Volume86
Issue number7
StatePublished - Apr 14 2000
Externally publishedYes

Fingerprint

Sudden Cardiac Death
Ventricular Tachycardia
Myocardial Infarction
Atrioventricular Block
Nerve Growth Factor
Dogs
Stellate Ganglion
Control Groups
Nerve Regeneration
Ventricular Fibrillation
Ambulatory Surgical Procedures
Staining and Labeling

Keywords

  • Cardiac innervation
  • Myocardial infarction
  • Nerve growth factor
  • Ventricular fibrillation
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Cao, J. M., Chen, L., KenKnight, B. H., Ohara, T., Lee, M. H., Tsai, J., ... Chen, P-S. (2000). Nerve sprouting and sudden cardiac death. Circulation Research, 86(7), 816-821.

Nerve sprouting and sudden cardiac death. / Cao, Ji Min; Chen, Lan; KenKnight, Bruce H.; Ohara, Toshihiko; Lee, Moon Hyoung; Tsai, Jerome; Lai, William W.; Karagueuzian, Hrayr S.; Wolf, Paul L.; Fishbein, Michael C.; Chen, Peng-Sheng.

In: Circulation Research, Vol. 86, No. 7, 14.04.2000, p. 816-821.

Research output: Contribution to journalArticle

Cao, JM, Chen, L, KenKnight, BH, Ohara, T, Lee, MH, Tsai, J, Lai, WW, Karagueuzian, HS, Wolf, PL, Fishbein, MC & Chen, P-S 2000, 'Nerve sprouting and sudden cardiac death', Circulation Research, vol. 86, no. 7, pp. 816-821.
Cao JM, Chen L, KenKnight BH, Ohara T, Lee MH, Tsai J et al. Nerve sprouting and sudden cardiac death. Circulation Research. 2000 Apr 14;86(7):816-821.
Cao, Ji Min ; Chen, Lan ; KenKnight, Bruce H. ; Ohara, Toshihiko ; Lee, Moon Hyoung ; Tsai, Jerome ; Lai, William W. ; Karagueuzian, Hrayr S. ; Wolf, Paul L. ; Fishbein, Michael C. ; Chen, Peng-Sheng. / Nerve sprouting and sudden cardiac death. In: Circulation Research. 2000 ; Vol. 86, No. 7. pp. 816-821.
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