Netrin and DCC

Axon guidance regulators at the intersection of nervous system development and cancer

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In recent years, a number of axon guidance genes, including Netrin (Net) and Deleted in Colorectal Cancer (DCC), have been implicated in human cancers. Many of the hallmarks of human cancer, such as cell growth, invasion, evasion of apoptosis, and formation of a blood supply to the tumor, involve cellular processes that are critical during nervous system development. Here, the roles of Net-DCC in the regulation of these cellular processes in tumors and developing neurons are discussed. The advantages of using Drosophila to study the function of Net-DCC and other axon guidance molecules in these cellular processes, as well as the potential for cancer therapeutics targeting Net-DCC are highlighted.

Original languageEnglish
Pages (from-to)602-610
Number of pages9
JournalCurrent Drug Targets
Volume10
Issue number7
DOIs
StatePublished - 2009

Fingerprint

Neurology
Nervous System
Tumors
Colorectal Neoplasms
Cell growth
Neurons
Neoplasms
Blood
Genes
Apoptosis
Molecules
Drosophila
Axons
Axon Guidance
Growth

Keywords

  • Angiogenesis
  • Apoptosis
  • Axon guidance
  • Cancer
  • DCC
  • Growth
  • Metastasis
  • Netrin

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Netrin and DCC : Axon guidance regulators at the intersection of nervous system development and cancer. / Scheel, Molly.

In: Current Drug Targets, Vol. 10, No. 7, 2009, p. 602-610.

Research output: Contribution to journalArticle

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