Neural correlates of olfactory change detection

Merav Sabri, Alexander Radnovich, Tie Q. Li, David Kareken

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Detecting changes in a stream of sensory information is vital to animals and humans. While there have been several studies of automatic change detection in various sensory modalities, olfactory change detection is largely unstudied. We investigated brain regions responsive to both passive and active detection of olfactory change using fMRI. Nine right-handed healthy, normosmic subjects (five men) were scanned in two conditions while breathing in synchrony with a metronome. In one condition, subjects mentally counted infrequent odors (Attend condition), whereas in the other condition, subjects' attention was directed elsewhere as they counted auditory tones (Ignore condition). Odors were delivered via a nasal cannula using a computer-controlled air-dilution olfactometer. Infrequently occurring olfactory stimuli evoked significant (P <. 05, corrected) activity in the subgenual cingulate and in central posterior orbitofrontal cortex, but only in the Ignore condition, as confirmed by direct comparison of the Ignore session with the Attend session (P <. 05, corrected). Subgenual cingulate and posterior orbital cortex may therefore play a role in detecting discrepant olfactory events while attention is otherwise engaged in another sensory modality.

Original languageEnglish
Pages (from-to)969-974
Number of pages6
JournalNeuroImage
Volume25
Issue number3
DOIs
StatePublished - Apr 15 2005

Fingerprint

Prefrontal Cortex
Gyrus Cinguli
Healthy Volunteers
Respiration
Air
Magnetic Resonance Imaging
Brain
Odorants
Cannula

Keywords

  • fMRI
  • Multimodal
  • Olfactory change detection
  • Olfactory stimulation
  • Selective attention

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Neural correlates of olfactory change detection. / Sabri, Merav; Radnovich, Alexander; Li, Tie Q.; Kareken, David.

In: NeuroImage, Vol. 25, No. 3, 15.04.2005, p. 969-974.

Research output: Contribution to journalArticle

Sabri, Merav ; Radnovich, Alexander ; Li, Tie Q. ; Kareken, David. / Neural correlates of olfactory change detection. In: NeuroImage. 2005 ; Vol. 25, No. 3. pp. 969-974.
@article{0ccf2134a53547cd9455ca8bc42d7e91,
title = "Neural correlates of olfactory change detection",
abstract = "Detecting changes in a stream of sensory information is vital to animals and humans. While there have been several studies of automatic change detection in various sensory modalities, olfactory change detection is largely unstudied. We investigated brain regions responsive to both passive and active detection of olfactory change using fMRI. Nine right-handed healthy, normosmic subjects (five men) were scanned in two conditions while breathing in synchrony with a metronome. In one condition, subjects mentally counted infrequent odors (Attend condition), whereas in the other condition, subjects' attention was directed elsewhere as they counted auditory tones (Ignore condition). Odors were delivered via a nasal cannula using a computer-controlled air-dilution olfactometer. Infrequently occurring olfactory stimuli evoked significant (P <. 05, corrected) activity in the subgenual cingulate and in central posterior orbitofrontal cortex, but only in the Ignore condition, as confirmed by direct comparison of the Ignore session with the Attend session (P <. 05, corrected). Subgenual cingulate and posterior orbital cortex may therefore play a role in detecting discrepant olfactory events while attention is otherwise engaged in another sensory modality.",
keywords = "fMRI, Multimodal, Olfactory change detection, Olfactory stimulation, Selective attention",
author = "Merav Sabri and Alexander Radnovich and Li, {Tie Q.} and David Kareken",
year = "2005",
month = "4",
day = "15",
doi = "10.1016/j.neuroimage.2004.12.033",
language = "English",
volume = "25",
pages = "969--974",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Neural correlates of olfactory change detection

AU - Sabri, Merav

AU - Radnovich, Alexander

AU - Li, Tie Q.

AU - Kareken, David

PY - 2005/4/15

Y1 - 2005/4/15

N2 - Detecting changes in a stream of sensory information is vital to animals and humans. While there have been several studies of automatic change detection in various sensory modalities, olfactory change detection is largely unstudied. We investigated brain regions responsive to both passive and active detection of olfactory change using fMRI. Nine right-handed healthy, normosmic subjects (five men) were scanned in two conditions while breathing in synchrony with a metronome. In one condition, subjects mentally counted infrequent odors (Attend condition), whereas in the other condition, subjects' attention was directed elsewhere as they counted auditory tones (Ignore condition). Odors were delivered via a nasal cannula using a computer-controlled air-dilution olfactometer. Infrequently occurring olfactory stimuli evoked significant (P <. 05, corrected) activity in the subgenual cingulate and in central posterior orbitofrontal cortex, but only in the Ignore condition, as confirmed by direct comparison of the Ignore session with the Attend session (P <. 05, corrected). Subgenual cingulate and posterior orbital cortex may therefore play a role in detecting discrepant olfactory events while attention is otherwise engaged in another sensory modality.

AB - Detecting changes in a stream of sensory information is vital to animals and humans. While there have been several studies of automatic change detection in various sensory modalities, olfactory change detection is largely unstudied. We investigated brain regions responsive to both passive and active detection of olfactory change using fMRI. Nine right-handed healthy, normosmic subjects (five men) were scanned in two conditions while breathing in synchrony with a metronome. In one condition, subjects mentally counted infrequent odors (Attend condition), whereas in the other condition, subjects' attention was directed elsewhere as they counted auditory tones (Ignore condition). Odors were delivered via a nasal cannula using a computer-controlled air-dilution olfactometer. Infrequently occurring olfactory stimuli evoked significant (P <. 05, corrected) activity in the subgenual cingulate and in central posterior orbitofrontal cortex, but only in the Ignore condition, as confirmed by direct comparison of the Ignore session with the Attend session (P <. 05, corrected). Subgenual cingulate and posterior orbital cortex may therefore play a role in detecting discrepant olfactory events while attention is otherwise engaged in another sensory modality.

KW - fMRI

KW - Multimodal

KW - Olfactory change detection

KW - Olfactory stimulation

KW - Selective attention

UR - http://www.scopus.com/inward/record.url?scp=16344384895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16344384895&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2004.12.033

DO - 10.1016/j.neuroimage.2004.12.033

M3 - Article

C2 - 15808997

AN - SCOPUS:16344384895

VL - 25

SP - 969

EP - 974

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 3

ER -