Neural MMP-28 expression precedes myelination during development and peripheral nerve repair

Sean R. Werner, Anthony Mescher, Anton W. Neff, Michael King, Shalini Chaturvedi, Kevin L. Duffin, Mark W. Harty, Rosamund C. Smith

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Mammalian matrix metalloproteinase 28 (MMP-28) is expressed in several normal adult tissues, and during cutaneous wound healing. We show that, in frog and mouse embryos, MMP-28 is expressed predominantly throughout the nervous system. Xenopus expression increases during neurulation and remains elevated through early limb development where it is expressed in nerves. In the mouse, neural expression peaks at embryonic day (E) 14 but remains detectable through E17. During frog hindlimb regeneration XMMP-28 is not initially expressed in the regenerating nerves but is detectable before myelination. Following hindlimb denervation, XMMP-28 expression is detectable along regenerating nerves before myelination. In embryonic rat neuron-glial co-cultures, MMP-28 decreases after the initiation of myelination. Incubation of embryonic brain tissue with purified MMP-28 leads to the degradation of multiple myelin proteins. These results suggest that MMP-28 plays an evolutionarily conserved role in neural development and is likely to modulate the axonal-glial extracellular microenvironment.

Original languageEnglish
Pages (from-to)2852-2864
Number of pages13
JournalDevelopmental Dynamics
Volume236
Issue number10
DOIs
StatePublished - Oct 2007

Fingerprint

Matrix Metalloproteinases
Peripheral Nerves
Hindlimb
Neuroglia
Anura
Neurulation
Myelin Proteins
Denervation
Coculture Techniques
Xenopus
Wound Healing
Nervous System
Regeneration
Embryonic Structures
Extremities
Neurons
Skin
Brain

Keywords

  • Metalloproteinase
  • MMP-28
  • Myelination
  • Neural development
  • Regeneration

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Neural MMP-28 expression precedes myelination during development and peripheral nerve repair. / Werner, Sean R.; Mescher, Anthony; Neff, Anton W.; King, Michael; Chaturvedi, Shalini; Duffin, Kevin L.; Harty, Mark W.; Smith, Rosamund C.

In: Developmental Dynamics, Vol. 236, No. 10, 10.2007, p. 2852-2864.

Research output: Contribution to journalArticle

Werner, SR, Mescher, A, Neff, AW, King, M, Chaturvedi, S, Duffin, KL, Harty, MW & Smith, RC 2007, 'Neural MMP-28 expression precedes myelination during development and peripheral nerve repair', Developmental Dynamics, vol. 236, no. 10, pp. 2852-2864. https://doi.org/10.1002/dvdy.21301
Werner, Sean R. ; Mescher, Anthony ; Neff, Anton W. ; King, Michael ; Chaturvedi, Shalini ; Duffin, Kevin L. ; Harty, Mark W. ; Smith, Rosamund C. / Neural MMP-28 expression precedes myelination during development and peripheral nerve repair. In: Developmental Dynamics. 2007 ; Vol. 236, No. 10. pp. 2852-2864.
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