Neural synchronization deficits to auditory stimulation in bipolar disorder

Brian F. O'Donnell, William P. Hetrick, Jenifer L. Vohs, Giri P. Krishnan, Christine A. Carroll, Anantha Shekhar

Research output: Contribution to journalArticle

77 Scopus citations


Patients with bipolar disorder show cognitive deficits and disorganized behavior, which may reflect a disturbance in neural synchronization. We tested whether EEG measures of auditory neural synchronization were abnormal in bipolar disorder. Nineteen symptomatic patients with bipolar disorder and 32 non-psychiatric control subjects were evaluated. Click trains (500 ms duration) presented at 20, 30, 40 and 50 Hz were used to evoke EEG synchronization. Patients with bipolar disorder showed reduced power across the frequencies of stimulation. Phase-locking across trials was also disturbed in bipolar disorder, consistent with poor phase synchronization between the stimulus and EEG. Abnormal high frequency neural synchronization may contribute to cognitive deficits in bipolar disorder.

Original languageEnglish (US)
Pages (from-to)1369-1372
Number of pages4
Issue number8
StatePublished - Jun 7 2004


  • Audition
  • Bipolar disorder
  • ERPs
  • Frequency entrainment
  • Steady state potentials
  • Synchronization

ASJC Scopus subject areas

  • Neuroscience(all)

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