Neuritic (Senile) plaques and filamentous changes in aged rhesus monkeys

Henryk M. Wiŝniewski, Bernardino Ghetti, Robert D. Terry

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194 Citations (Scopus)

Abstract

Three rhesus monkeys, whose approximate ages were 16 to 18 years old, and one 22 to 23 years old, were studied for age changes in the nervous system. The brains of all four were slightly shrunken and the meninges were fibrotic. The vessels were stiff and fibrosed, but were not atheromatous. The lateral ventricles were mildly dilated. Bodian preparations of the oldest monkey and of one of the 16- to 18-year-old monkeys revealed the presence of ncuritic (senile) plaques. Serial one-micron toluidinc blue-stained sections showed that some plaques were closely associated with capillaries. Electron microscopic studies revealed that the plaques were identical to those of human Alzheimer's disease except that the typical twisted tubules were absent. Outside the plaques there were scattered neurites showing degeneration of the type found in the neuritic plaques. Furthermore, two forms of rare pathological fibrillar material were found in 3 animals. One was made up of pairs of helically wound 100 A filaments with a twist every 500 A. The other fibrillar structures were made up of bundles of parallel filamentous elements, each about 130 A thick, with a distinctly granular structure on longitudinal section. A list of other abnormalities includes vascular amyloidosis, lipofuscin accumulation, dark neurons undergoing phagocytosis, myelin remodeling, aggregates of large electron-dense droplets, enlarged mitochondria and mitochondria with paracrystallinc inclusions, corpora amylacea, Rosenthal fibers and two types of virus-like particles.

Original languageEnglish (US)
Pages (from-to)566-584
Number of pages19
JournalJournal of Neuropathology and Experimental Neurology
Volume32
Issue number4
StatePublished - 1973
Externally publishedYes

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Amyloid Plaques
Macaca mulatta
Haplorhini
Mitochondria
Electrons
Lipofuscin
Meninges
Lateral Ventricles
Amyloidosis
Neurites
Myelin Sheath
Phagocytosis
Virion
Nervous System
Blood Vessels
Alzheimer Disease
Neurons
Wounds and Injuries
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Cellular and Molecular Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Neuritic (Senile) plaques and filamentous changes in aged rhesus monkeys. / Wiŝniewski, Henryk M.; Ghetti, Bernardino; Terry, Robert D.

In: Journal of Neuropathology and Experimental Neurology, Vol. 32, No. 4, 1973, p. 566-584.

Research output: Contribution to journalArticle

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