Neuroanatomic substrates of semantic memory impairment in Alzheimer's disease: Patterns of functional MRI activation

Andrew Saykin, Laura A. Flashman, Sally A. Frutiger, Sterling C. Johnson, Alexander C. Mamourian, Chad H. Moritz, Judith R. O'Jile, Henry J. Riordan, Robert B. Santulli, Cynthia A. Smith, John B. Weaver

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Impairment in semantic processing occurs early in Alzheimer's disease (AD) and differential impact on subtypes of semantic relations have been reported, yet there is little data on the neuroanatomic basis of these deficits. Patients with mild AD and healthy controls underwent 3 functional MRI auditory stimulation tasks requiring semantic or phonological decisions (match-mismatch) about word pairs (category-exemplar, category-function, pseudoword). Patients showed a significant performance deficit only on the exemplar task. On voxel-based fMRI activation analyses, controls showed a clear activation focus in the left superior temporal gyrus for the phonological task; patients showed additional foci in the left dorsolateral prefrontal and bilateral cingulate areas. On the semantic tasks, predominant activation foci were seen in the inferior and middle frontal gyrus (left greater than right) in both groups but patients showed additional activation suggesting compensatory recruitment of locally expanded foci and remote regions, for example, right frontal activation during the exemplar task. Covariance analyses indicated that exemplar task performance was strongly related to signal increase in bilateral medial prefrontal cortex. The authors conclude that fMRI can reveal similarities and differences in functional neuroanatomical processing of semantic and phonological information in mild AD compared to healthy elderly, and can help to bridge cognitive and neural investigations of the integrity of semantic networks in AD.

Original languageEnglish (US)
Pages (from-to)377-392
Number of pages16
JournalJournal of the International Neuropsychological Society
Volume5
Issue number5
DOIs
StatePublished - Jul 1999
Externally publishedYes

Fingerprint

Semantics
Alzheimer Disease
Magnetic Resonance Imaging
Prefrontal Cortex
Activation Analysis
Acoustic Stimulation
Gyrus Cinguli
Task Performance and Analysis
Temporal Lobe

Keywords

  • Alzheimer disease
  • Functional MRI
  • Phonological
  • Semantic memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Neuroanatomic substrates of semantic memory impairment in Alzheimer's disease : Patterns of functional MRI activation. / Saykin, Andrew; Flashman, Laura A.; Frutiger, Sally A.; Johnson, Sterling C.; Mamourian, Alexander C.; Moritz, Chad H.; O'Jile, Judith R.; Riordan, Henry J.; Santulli, Robert B.; Smith, Cynthia A.; Weaver, John B.

In: Journal of the International Neuropsychological Society, Vol. 5, No. 5, 07.1999, p. 377-392.

Research output: Contribution to journalArticle

Saykin, A, Flashman, LA, Frutiger, SA, Johnson, SC, Mamourian, AC, Moritz, CH, O'Jile, JR, Riordan, HJ, Santulli, RB, Smith, CA & Weaver, JB 1999, 'Neuroanatomic substrates of semantic memory impairment in Alzheimer's disease: Patterns of functional MRI activation', Journal of the International Neuropsychological Society, vol. 5, no. 5, pp. 377-392. https://doi.org/10.1017/S135561779955501X
Saykin, Andrew ; Flashman, Laura A. ; Frutiger, Sally A. ; Johnson, Sterling C. ; Mamourian, Alexander C. ; Moritz, Chad H. ; O'Jile, Judith R. ; Riordan, Henry J. ; Santulli, Robert B. ; Smith, Cynthia A. ; Weaver, John B. / Neuroanatomic substrates of semantic memory impairment in Alzheimer's disease : Patterns of functional MRI activation. In: Journal of the International Neuropsychological Society. 1999 ; Vol. 5, No. 5. pp. 377-392.
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