Neurochemical abnormalities in unmedicated bipolar depression and mania

A 2D 1H MRS investigation

Jun Xu, Ulrike Dydak, Jaroslaw Harezlak, Jonathan Nixon, Mario Dzemidzic, Abigail D. Gunn, Harish S. Karne, Amit Anand

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The neurobiology and neurochemistry of bipolar disorder and its different phases are poorly understood. This study investigated metabolite abnormalities in both unmedicated bipolar depression as well as mania using 2D 1H magnetic resonance spectroscopy imaging (MRSI). MRSI data were obtained from 24 unmedicated bipolar disorder (BP) subjects (12 (hypo)manic (BPM)) and 12 depressed (BPD), and 20 closely matched healthy controls. 2D 1H MRSI data were collected from a 15-mm axial slice placed along the anterior commissure-posterior commissure (AC-PC) line to measure brain metabolites bilaterally in the thalamus and also the anterior and posterior cingulate cortex (ACC and PCC). Brain Lac/Cr levels were significantly increased in the BP group as a whole compared to healthy controls. Glutamate abnormalities varied across bipolar state as well as brain region: significantly increased Glx/Cr values were found in the left thalamus in BPD, but BPM had decreased Glu/Cr and Glx/Cr levels in the PCC when compared to healthy controls and decreased Glu/Cr levels even when compared to the BPD subjects group. The findings of the study point to state-related abnormalities of oxidative and glutamate metabolism in bipolar disorder.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalPsychiatry Research - Neuroimaging
Volume213
Issue number3
DOIs
StatePublished - Sep 30 2013

Fingerprint

Bipolar Disorder
Magnetic Resonance Spectroscopy
Gyrus Cinguli
Magnetic Resonance Imaging
Thalamus
Glutamic Acid
Brain
Neurochemistry
Neurobiology
Proton Magnetic Resonance Spectroscopy

Keywords

  • Bipolar disorder
  • Depression
  • Glutamate
  • Lactate
  • Mania
  • MRS

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

Neurochemical abnormalities in unmedicated bipolar depression and mania : A 2D 1H MRS investigation. / Xu, Jun; Dydak, Ulrike; Harezlak, Jaroslaw; Nixon, Jonathan; Dzemidzic, Mario; Gunn, Abigail D.; Karne, Harish S.; Anand, Amit.

In: Psychiatry Research - Neuroimaging, Vol. 213, No. 3, 30.09.2013, p. 235-241.

Research output: Contribution to journalArticle

Xu, Jun ; Dydak, Ulrike ; Harezlak, Jaroslaw ; Nixon, Jonathan ; Dzemidzic, Mario ; Gunn, Abigail D. ; Karne, Harish S. ; Anand, Amit. / Neurochemical abnormalities in unmedicated bipolar depression and mania : A 2D 1H MRS investigation. In: Psychiatry Research - Neuroimaging. 2013 ; Vol. 213, No. 3. pp. 235-241.
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