Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats

P. E. Penn, W. J. McBride, L. Lumeng, T. M. Gaff, T. K. Li

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

The levels of serotonin (5-HT), 5-hydroxyindoleacetic acid, tyrosine (TYR), norepinephrine (NE), acetylcholine, GABA, glutamate (GLU), aspartate (ASP), alanine, glycine (GLY) and taurine were measured in the CNS of adult male rats selectively inbred to the F8 generation for alcohol preference (P) and non-preference (NP). With respect to the values found in the NP group, higher levels of 5-HT, GABA, GLU and GLY and lower levels of ASP were found in the diencephalon-mesencephalon (D-M) and higher levels of NE were found in the telencephalon (TEL) of the P group. The animals in the P and NP strains were further subdivided into two additional groups, one given only H2O (W) and the second given 10% ethanol (A) during a one week period, thereby producing four groups (NP-W, NP-A, P-W and P-A). With these conditions, the level of (a) TYR in the D-M was higher in the P-A and NP-A animals than in the P-W and NP-W groups, respectively; (b) 5-HT in the TEL was higher in the NP-A group than NP-W group; and (c) GABA in the TEL was higher in the P-A P-W animals. No differences were observed in the cerebellum between the two strains or between the subgroups within each strain. The present study also demonstrated that the P animals will work in an operant situation to obtain 10% ethanol, even when H2O is freely available, and will voluntarily bar-press up to 6-7 times for each ethanol reinforcement.

Original languageEnglish
Pages (from-to)475-481
Number of pages7
JournalPharmacology Biochemistry and Behavior
Volume8
Issue number4
DOIs
StatePublished - 1978

Fingerprint

Telencephalon
Rats
Serotonin
Animals
Alcohols
gamma-Aminobutyric Acid
Diencephalon
Ethanol
Mesencephalon
Aspartic Acid
Glycine
Tyrosine
Glutamic Acid
Norepinephrine
Hydroxyindoleacetic Acid
Taurine
Alanine
Cerebellum
Acetylcholine
Reinforcement

Keywords

  • Acetylcholine
  • Alcohol-preferring rats
  • Ethanol
  • GABA
  • Glutamate Asparate
  • Glycine
  • Norepinephrine
  • Operant behavior
  • Serotonin
  • Taurine
  • Tyrosine

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats. / Penn, P. E.; McBride, W. J.; Lumeng, L.; Gaff, T. M.; Li, T. K.

In: Pharmacology Biochemistry and Behavior, Vol. 8, No. 4, 1978, p. 475-481.

Research output: Contribution to journalArticle

Penn, P. E. ; McBride, W. J. ; Lumeng, L. ; Gaff, T. M. ; Li, T. K. / Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats. In: Pharmacology Biochemistry and Behavior. 1978 ; Vol. 8, No. 4. pp. 475-481.
@article{887841040ee249a4adc484097910f89d,
title = "Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats",
abstract = "The levels of serotonin (5-HT), 5-hydroxyindoleacetic acid, tyrosine (TYR), norepinephrine (NE), acetylcholine, GABA, glutamate (GLU), aspartate (ASP), alanine, glycine (GLY) and taurine were measured in the CNS of adult male rats selectively inbred to the F8 generation for alcohol preference (P) and non-preference (NP). With respect to the values found in the NP group, higher levels of 5-HT, GABA, GLU and GLY and lower levels of ASP were found in the diencephalon-mesencephalon (D-M) and higher levels of NE were found in the telencephalon (TEL) of the P group. The animals in the P and NP strains were further subdivided into two additional groups, one given only H2O (W) and the second given 10{\%} ethanol (A) during a one week period, thereby producing four groups (NP-W, NP-A, P-W and P-A). With these conditions, the level of (a) TYR in the D-M was higher in the P-A and NP-A animals than in the P-W and NP-W groups, respectively; (b) 5-HT in the TEL was higher in the NP-A group than NP-W group; and (c) GABA in the TEL was higher in the P-A P-W animals. No differences were observed in the cerebellum between the two strains or between the subgroups within each strain. The present study also demonstrated that the P animals will work in an operant situation to obtain 10{\%} ethanol, even when H2O is freely available, and will voluntarily bar-press up to 6-7 times for each ethanol reinforcement.",
keywords = "Acetylcholine, Alcohol-preferring rats, Ethanol, GABA, Glutamate Asparate, Glycine, Norepinephrine, Operant behavior, Serotonin, Taurine, Tyrosine",
author = "Penn, {P. E.} and McBride, {W. J.} and L. Lumeng and Gaff, {T. M.} and Li, {T. K.}",
year = "1978",
doi = "10.1016/0091-3057(78)90087-4",
language = "English",
volume = "8",
pages = "475--481",
journal = "Pharmacology, Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats

AU - Penn, P. E.

AU - McBride, W. J.

AU - Lumeng, L.

AU - Gaff, T. M.

AU - Li, T. K.

PY - 1978

Y1 - 1978

N2 - The levels of serotonin (5-HT), 5-hydroxyindoleacetic acid, tyrosine (TYR), norepinephrine (NE), acetylcholine, GABA, glutamate (GLU), aspartate (ASP), alanine, glycine (GLY) and taurine were measured in the CNS of adult male rats selectively inbred to the F8 generation for alcohol preference (P) and non-preference (NP). With respect to the values found in the NP group, higher levels of 5-HT, GABA, GLU and GLY and lower levels of ASP were found in the diencephalon-mesencephalon (D-M) and higher levels of NE were found in the telencephalon (TEL) of the P group. The animals in the P and NP strains were further subdivided into two additional groups, one given only H2O (W) and the second given 10% ethanol (A) during a one week period, thereby producing four groups (NP-W, NP-A, P-W and P-A). With these conditions, the level of (a) TYR in the D-M was higher in the P-A and NP-A animals than in the P-W and NP-W groups, respectively; (b) 5-HT in the TEL was higher in the NP-A group than NP-W group; and (c) GABA in the TEL was higher in the P-A P-W animals. No differences were observed in the cerebellum between the two strains or between the subgroups within each strain. The present study also demonstrated that the P animals will work in an operant situation to obtain 10% ethanol, even when H2O is freely available, and will voluntarily bar-press up to 6-7 times for each ethanol reinforcement.

AB - The levels of serotonin (5-HT), 5-hydroxyindoleacetic acid, tyrosine (TYR), norepinephrine (NE), acetylcholine, GABA, glutamate (GLU), aspartate (ASP), alanine, glycine (GLY) and taurine were measured in the CNS of adult male rats selectively inbred to the F8 generation for alcohol preference (P) and non-preference (NP). With respect to the values found in the NP group, higher levels of 5-HT, GABA, GLU and GLY and lower levels of ASP were found in the diencephalon-mesencephalon (D-M) and higher levels of NE were found in the telencephalon (TEL) of the P group. The animals in the P and NP strains were further subdivided into two additional groups, one given only H2O (W) and the second given 10% ethanol (A) during a one week period, thereby producing four groups (NP-W, NP-A, P-W and P-A). With these conditions, the level of (a) TYR in the D-M was higher in the P-A and NP-A animals than in the P-W and NP-W groups, respectively; (b) 5-HT in the TEL was higher in the NP-A group than NP-W group; and (c) GABA in the TEL was higher in the P-A P-W animals. No differences were observed in the cerebellum between the two strains or between the subgroups within each strain. The present study also demonstrated that the P animals will work in an operant situation to obtain 10% ethanol, even when H2O is freely available, and will voluntarily bar-press up to 6-7 times for each ethanol reinforcement.

KW - Acetylcholine

KW - Alcohol-preferring rats

KW - Ethanol

KW - GABA

KW - Glutamate Asparate

KW - Glycine

KW - Norepinephrine

KW - Operant behavior

KW - Serotonin

KW - Taurine

KW - Tyrosine

UR - http://www.scopus.com/inward/record.url?scp=0018179263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018179263&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(78)90087-4

DO - 10.1016/0091-3057(78)90087-4

M3 - Article

C2 - 27820

AN - SCOPUS:0018179263

VL - 8

SP - 475

EP - 481

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

SN - 0091-3057

IS - 4

ER -