Neurochemical changes following the administration of depleters of biogenic monoamines

J. D. Lane, J. E. Smith, P. A. Shea, W. J. McBride

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Abstract

A variety of drugs which were thought to selectively effect the synthesis, release or reuptake of the biogenic monoamines, and thereby deplete their stores in brain, were administered to rats. The animals were given intraperitoneal injections of reserpine, α-methyl-meta-tyrosine, α-methyl-para-tyrosine, para-cholorophenylalanine and tetrabenazine, and were killed at intervals known to cause maximum depletion of serotonin, dopamine and norepinephrine. When compared to saline controls, the drugs depleted the respective monoamines, as expected, but changes in the levels of acetylcholine, alanine, glycine, γ-aminobutyric acid, and aspartate and glutamate were also observed.

Original languageEnglish (US)
Pages (from-to)1663-1667
Number of pages5
JournalLife Sciences
Volume19
Issue number11
DOIs
StatePublished - Dec 1 1976

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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