Neurochemical changes following the administration of depleters of biogenic monoamines

J. D. Lane, J. E. Smith, P. A. Shea, W. J. McBride

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A variety of drugs which were thought to selectively effect the synthesis, release or reuptake of the biogenic monoamines, and thereby deplete their stores in brain, were administered to rats. The animals were given intraperitoneal injections of reserpine, α-methyl-meta-tyrosine, α-methyl-para-tyrosine, para-cholorophenylalanine and tetrabenazine, and were killed at intervals known to cause maximum depletion of serotonin, dopamine and norepinephrine. When compared to saline controls, the drugs depleted the respective monoamines, as expected, but changes in the levels of acetylcholine, alanine, glycine, γ-aminobutyric acid, and aspartate and glutamate were also observed.

Original languageEnglish
Pages (from-to)1663-1667
Number of pages5
JournalLife Sciences
Volume19
Issue number11
DOIs
StatePublished - Dec 1 1976

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Biogenic Monoamines
Tetrabenazine
Aminobutyrates
Drug and Narcotic Control
Reserpine
Intraperitoneal Injections
Aspartic Acid
Alanine
Glycine
Acetylcholine
Tyrosine
Glutamic Acid
Dopamine
Serotonin
Norepinephrine
Brain
Pharmaceutical Preparations
Rats
Animals
3-tyrosine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Neurochemical changes following the administration of depleters of biogenic monoamines. / Lane, J. D.; Smith, J. E.; Shea, P. A.; McBride, W. J.

In: Life Sciences, Vol. 19, No. 11, 01.12.1976, p. 1663-1667.

Research output: Contribution to journalArticle

Lane, J. D. ; Smith, J. E. ; Shea, P. A. ; McBride, W. J. / Neurochemical changes following the administration of depleters of biogenic monoamines. In: Life Sciences. 1976 ; Vol. 19, No. 11. pp. 1663-1667.
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