Neurochemical changes following the administration of precursors of biogenic amines

J. E. Smith, J. D. Lane, P. A. Shea, W. J. McBride

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24 Scopus citations

Abstract

Male Wistar rats were injected intraperitoneally with either saline, L-trytophan, D,L-5hydroxytryptophan, L-tyrosine, L-DOPA or choline and killed by the near-freezing method 15 and 45 min after injection. The brains were removed, pulverized and acetylcholine, dopamine, norepinephrine, 5-hydroxytryptamine, aspartate, glutamate, glycine and γ-aminobuttyric acid wwere extracted and concurrently measured using previously reported methods. Compared to saline injected controls, some precursors not only resulted in changes in the specific neurotransmiter systems being pertubated, but also changes in the content of other neurotransmitters.

Original languageEnglish (US)
Pages (from-to)301-306
Number of pages6
JournalLife Sciences
Volume21
Issue number3
DOIs
StatePublished - Aug 1 1977

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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