Neurochemical changes following the administration of precursors of biogenic amines

J. E. Smith, J. D. Lane, P. A. Shea, W. J. McBride

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Male Wistar rats were injected intraperitoneally with either saline, L-trytophan, D,L-5hydroxytryptophan, L-tyrosine, L-DOPA or choline and killed by the near-freezing method 15 and 45 min after injection. The brains were removed, pulverized and acetylcholine, dopamine, norepinephrine, 5-hydroxytryptamine, aspartate, glutamate, glycine and γ-aminobuttyric acid wwere extracted and concurrently measured using previously reported methods. Compared to saline injected controls, some precursors not only resulted in changes in the specific neurotransmiter systems being pertubated, but also changes in the content of other neurotransmitters.

Original languageEnglish
Pages (from-to)301-306
Number of pages6
JournalLife Sciences
Volume21
Issue number3
DOIs
StatePublished - Aug 1 1977

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Biogenic Amines
Choline
Aspartic Acid
Freezing
Glycine
Acetylcholine
Neurotransmitter Agents
Tyrosine
Rats
Glutamic Acid
Dopamine
Brain
Serotonin
Norepinephrine
Acids
Wistar Rats
Injections

ASJC Scopus subject areas

  • Pharmacology

Cite this

Neurochemical changes following the administration of precursors of biogenic amines. / Smith, J. E.; Lane, J. D.; Shea, P. A.; McBride, W. J.

In: Life Sciences, Vol. 21, No. 3, 01.08.1977, p. 301-306.

Research output: Contribution to journalArticle

Smith, J. E. ; Lane, J. D. ; Shea, P. A. ; McBride, W. J. / Neurochemical changes following the administration of precursors of biogenic amines. In: Life Sciences. 1977 ; Vol. 21, No. 3. pp. 301-306.
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