Neurochemical correlates of behavior. Content of tryptophan derivatives in a nerve-ending fraction isolated from 3 brain areas of the pigeon during behavioral depression following an injection of tryptophan

J. E. Smith, J. N. Hingtgen, W. J. McBride, M. H. Aprison

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Pigeons working on a multiple fixed ratio 50, fixed interval 10 schedule for food reinforcement were killed at 0, 50, 90, 150 and 240 min after an i.m. injection of 300 mg/kg L tryptophan. The levels of tryptophan, 5 hydroxytryptophan, 5 hydroxytryptamine, 5 hydroxyindole acetic acid, tyrosine, dopamine and norepinephrine were concurrently measured in crude nerve ending fractions (P2) isolated from the telencephalon, diencephalon plus mesencephalon and pons plus medulla oblongata of each pigeon. Increases in 5 hydroxytryptamine levels in the nerve ending fraction from the telencephalon were correlated with the onset of the decreased response rates, whereas a return to baseline responding was correlated with a return to normal serotonin levels in this fraction. Changes in dopamine or norepinephrine were not related to the onset of or recovery from the decreased response rate. One group of pigeons were found which did not display any behavioral disruption even though each had received an injection of L tryptophan; the content of 5 hydroxytryptophan, 5 hydroxytryptamine and 5 hydroxyindoleacetic acid in the nerve ending fraction isolated from the telencephalon of these birds did not differ from control values.

Original languageEnglish (US)
Pages (from-to)747-751
Number of pages5
JournalJournal of Neurochemistry
Volume27
Issue number3
DOIs
StatePublished - Sep 1976

Fingerprint

Nerve Endings
Columbidae
Tryptophan
Telencephalon
Brain
Serotonin
Depression
Derivatives
5-Hydroxytryptophan
Injections
Dopamine
Norepinephrine
Reinforcement Schedule
Diencephalon
Medulla Oblongata
Hydroxyindoleacetic Acid
Pons
Birds
Mesencephalon
Acetic Acid

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

@article{b1af8a702f5343b8830a0ea1a1a1f527,
title = "NEUROCHEMICAL CORRELATES OF BEHAVIOR: CONTENT OF TRYPTOPHAN, 5‐HYDROXYTRYPTOPHAN, SEROTONIN, 5‐HYDROXYINDOLEACETIC ACID, TYROSPNE, DOPAMINE AND NOREPPNEPHRPNE IN A NERVE ENDING FRACTION ISOLATED FROM THREE BRAIN AREAS OF THE PIGEON DURPNG THE PERIOD OF BEHAVIORAL DEPRESSION FOLLOWPWG AN INJECTION OF TRYPTOPHAN",
abstract = "Pigeons working on a multiple fixed ratio 50, fixed interval 10 schedule for food reinforcement were killed at 0, 50, 90, 150 and 240 min after an i.m. injection of 300 mg/kg L tryptophan. The levels of tryptophan, 5 hydroxytryptophan, 5 hydroxytryptamine, 5 hydroxyindole acetic acid, tyrosine, dopamine and norepinephrine were concurrently measured in crude nerve ending fractions (P2) isolated from the telencephalon, diencephalon plus mesencephalon and pons plus medulla oblongata of each pigeon. Increases in 5 hydroxytryptamine levels in the nerve ending fraction from the telencephalon were correlated with the onset of the decreased response rates, whereas a return to baseline responding was correlated with a return to normal serotonin levels in this fraction. Changes in dopamine or norepinephrine were not related to the onset of or recovery from the decreased response rate. One group of pigeons were found which did not display any behavioral disruption even though each had received an injection of L tryptophan; the content of 5 hydroxytryptophan, 5 hydroxytryptamine and 5 hydroxyindoleacetic acid in the nerve ending fraction isolated from the telencephalon of these birds did not differ from control values.",
author = "Smith, {J. E.} and Hingtgen, {J. N.} and McBride, {W. J.} and Aprison, {M. H.}",
year = "1976",
month = "9",
doi = "10.1111/j.1471-4159.1976.tb10403.x",
language = "English (US)",
volume = "27",
pages = "747--751",
journal = "Journal of Neurochemistry",
issn = "0022-3042",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - NEUROCHEMICAL CORRELATES OF BEHAVIOR

T2 - CONTENT OF TRYPTOPHAN, 5‐HYDROXYTRYPTOPHAN, SEROTONIN, 5‐HYDROXYINDOLEACETIC ACID, TYROSPNE, DOPAMINE AND NOREPPNEPHRPNE IN A NERVE ENDING FRACTION ISOLATED FROM THREE BRAIN AREAS OF THE PIGEON DURPNG THE PERIOD OF BEHAVIORAL DEPRESSION FOLLOWPWG AN INJECTION OF TRYPTOPHAN

AU - Smith, J. E.

AU - Hingtgen, J. N.

AU - McBride, W. J.

AU - Aprison, M. H.

PY - 1976/9

Y1 - 1976/9

N2 - Pigeons working on a multiple fixed ratio 50, fixed interval 10 schedule for food reinforcement were killed at 0, 50, 90, 150 and 240 min after an i.m. injection of 300 mg/kg L tryptophan. The levels of tryptophan, 5 hydroxytryptophan, 5 hydroxytryptamine, 5 hydroxyindole acetic acid, tyrosine, dopamine and norepinephrine were concurrently measured in crude nerve ending fractions (P2) isolated from the telencephalon, diencephalon plus mesencephalon and pons plus medulla oblongata of each pigeon. Increases in 5 hydroxytryptamine levels in the nerve ending fraction from the telencephalon were correlated with the onset of the decreased response rates, whereas a return to baseline responding was correlated with a return to normal serotonin levels in this fraction. Changes in dopamine or norepinephrine were not related to the onset of or recovery from the decreased response rate. One group of pigeons were found which did not display any behavioral disruption even though each had received an injection of L tryptophan; the content of 5 hydroxytryptophan, 5 hydroxytryptamine and 5 hydroxyindoleacetic acid in the nerve ending fraction isolated from the telencephalon of these birds did not differ from control values.

AB - Pigeons working on a multiple fixed ratio 50, fixed interval 10 schedule for food reinforcement were killed at 0, 50, 90, 150 and 240 min after an i.m. injection of 300 mg/kg L tryptophan. The levels of tryptophan, 5 hydroxytryptophan, 5 hydroxytryptamine, 5 hydroxyindole acetic acid, tyrosine, dopamine and norepinephrine were concurrently measured in crude nerve ending fractions (P2) isolated from the telencephalon, diencephalon plus mesencephalon and pons plus medulla oblongata of each pigeon. Increases in 5 hydroxytryptamine levels in the nerve ending fraction from the telencephalon were correlated with the onset of the decreased response rates, whereas a return to baseline responding was correlated with a return to normal serotonin levels in this fraction. Changes in dopamine or norepinephrine were not related to the onset of or recovery from the decreased response rate. One group of pigeons were found which did not display any behavioral disruption even though each had received an injection of L tryptophan; the content of 5 hydroxytryptophan, 5 hydroxytryptamine and 5 hydroxyindoleacetic acid in the nerve ending fraction isolated from the telencephalon of these birds did not differ from control values.

UR - http://www.scopus.com/inward/record.url?scp=0017089109&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017089109&partnerID=8YFLogxK

U2 - 10.1111/j.1471-4159.1976.tb10403.x

DO - 10.1111/j.1471-4159.1976.tb10403.x

M3 - Article

C2 - 1085813

AN - SCOPUS:0017089109

VL - 27

SP - 747

EP - 751

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

SN - 0022-3042

IS - 3

ER -