Neurochemistry in the pathophysiology of autism

Christopher J. McDougle, Craig A. Erickson, Kimberly A. Stigler, David J. Posey

Research output: Contribution to journalReview article

88 Scopus citations


Significant progress has been made in the search for underlying pathophysiologic mechanisms in autism over the past 50 years. The cause of the disorder, however, remains largely unknown. This article reviews neurochemical contributions to the pathophysiology of autism with a focus on monoamines, glutamate/γ-aminobutyric acid systems, and neuropeptides. As these efforts move forward, it will be important to begin to integrate genetic studies with those involving neuroimaging and postmortem research in each of these 3 areas, as well as with pharmacologic treatment approaches.

Original languageEnglish (US)
Pages (from-to)9-18
Number of pages10
JournalJournal of Clinical Psychiatry
Issue numberSUPPL. 10
StatePublished - 2005

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    McDougle, C. J., Erickson, C. A., Stigler, K. A., & Posey, D. J. (2005). Neurochemistry in the pathophysiology of autism. Journal of Clinical Psychiatry, 66(SUPPL. 10), 9-18.