Neuroenteric Staining as a Tool in the Evaluation of Pediatric Motility Disorders

Shamaila H. Waseem, Muhammad Idrees, Joseph Croffie

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The diagnosis of enteric neuromuscular disorders has come a long way since the first description of an enteric neuropathic disorder by the Danish physician Harald Hirschsprung in 1886. Advances in specialized enteric histopathological staining techniques have made it possible to identify subtle neuropathies and myopathies that cause intestinal motility disorders, from the common and now better understood and relatively easily diagnosed Hirschsprung’s disease to the less common and more severe and not well-characterized chronic idiopathic intestinal pseudoobstruction, which continues to present a diagnostic challenge to the gastroenterologist and histopathologist alike. This article will discuss the common gastrointestinal motility disorders and some of the specialized histological stains, such as the relatively common enzyme stain, acetylcholinesterase, used to diagnose Hirschsprung’s disease; advanced tinctorial stains, such as Masson trichrome, which may aid in diagnosis of enteric myopathies causing pseudoobstruction; and immunohistochemical stains such as C-Kit or PG 9.5, which may aid in the diagnosis of enteric neuropathies causing pseudoobstruction.

Original languageEnglish
Article number30
JournalCurrent Gastroenterology Reports
Volume17
Issue number8
DOIs
StatePublished - Aug 6 2015

Fingerprint

Coloring Agents
Pediatrics
Staining and Labeling
Hirschsprung Disease
Gastrointestinal Motility
Muscular Diseases
Intestinal Pseudo-Obstruction
Acetylcholinesterase
Physicians
Enzymes

Keywords

  • Achalasia
  • Gastroparesis
  • Hirschsprung’s disease
  • Histochemical stains
  • Immunohistochemical stains
  • Intestinal pseudoobstruction
  • Motility disorders
  • Neuroenteric staining

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Neuroenteric Staining as a Tool in the Evaluation of Pediatric Motility Disorders. / Waseem, Shamaila H.; Idrees, Muhammad; Croffie, Joseph.

In: Current Gastroenterology Reports, Vol. 17, No. 8, 30, 06.08.2015.

Research output: Contribution to journalArticle

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