Neurofibrillary degeneration in cultured adult mouse neurons induced by maytansine

Seung U. Kim, Masanori Tomonaga, Bernardino Ghetti

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The effects of maytansine, an antimitotic compound isolated from an African plant, were studied by light and electron microscopy in dissociated cell cultures of adult mouse dorsal root ganglia. Maytansine at 10-100 ng/ml concentration caused reversible, concentration-dependent, inhibition of microtubule assembly and induction of a large amount of 10 nm filaments in the cytoplasm of cultured neurons and Schwann cells.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalActa Neuropathologica
Volume52
Issue number2
DOIs
StatePublished - Jan 1 1980

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Keywords

  • Adult mouse
  • Aging
  • Dorsal root ganglion
  • Maytansine
  • Neurofibrillary degeneration
  • Tissue culture

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

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