Neurofibrillary tangles of the Indiana kindred of Gerstmann-Sträussler-Scheinker disease share antigenic determinants with those of Alzheimer disease

Giorgio Giaccone, Fabrizio Tagliavini, Laura Verga, Blas Frangione, Martin R. Farlow, Orso Bugiani, Bernardino Ghetti

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

In the Indiana kindred of Gerstmann-Sträussler-Scheinker disease, neurofibrillary tangles (NFT) with paired helical filaments (PHF) are numerous, widespread and consistently present in the cerebral cortex and several subcortical nuclei. Such tangles share antigenic determinants with those of Alzheimer disease; in fact, they are recognized by Alz50, anti-PHF and anti-ubiquitin antibodies. Thus, NFT with structural and immunocytochemical similarities are present in two distinct forms of amyloidosis of the central nervous system, i.e. the Indiana kindred of Gerstmann-Sträussler-Scheinker disease and Alzheimer disease.

Original languageEnglish (US)
Pages (from-to)325-329
Number of pages5
JournalBrain research
Volume530
Issue number2
DOIs
StatePublished - Oct 22 1990

Keywords

  • Alz50
  • Alzheimer disease
  • Amyloid plaque
  • Gerstmann-Sträussler-Scheinker disease
  • Immunohistochemistry
  • Neuritic plaque
  • Neurofibrillary tangle
  • Neuropil thread
  • Paired helical filament
  • Ubiquitin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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