Neurofibromatosis type 1 as a model system to study molecular mechanisms of autism spectrum disorder symptoms

Andrei I. Molosh, Anantha Shekhar

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Neurofibromatosis type 1 (NF1) is monogenic neurodevelopmental disorder caused by mutation of NF1 gene, which leads to increased susceptibility to various tumors formations. Additionally, majority of patients with NF1 are experience high incidence of cognitive deficits. Particularly, we review the growing number of reports demonstrated a higher incidence of autism spectrum disorder (ASD) in individuals with NF1. In this review we also discuss face validity of preclinical Nf1 mouse models. Then we describe discoveries from these animal models that have uncovered the deficiencies in the regulation of Ras and other intracellular pathways as critical mechanisms underlying the Nf1 cognitive problems. We also summarize and interpret recent preclinical and clinical studies that point toward potential pharmacological therapies for NF1 patients.

Original languageEnglish (US)
Title of host publicationProgress in Brain Research
PublisherElsevier B.V.
Pages37-62
Number of pages26
DOIs
StatePublished - 2018

Publication series

NameProgress in Brain Research
Volume241
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

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Keywords

  • Autism spectrum disorders
  • Behavior
  • Cognition
  • Mouse models
  • Neurofibromatosis type 1
  • PAK inhibitors

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Molosh, A. I., & Shekhar, A. (2018). Neurofibromatosis type 1 as a model system to study molecular mechanisms of autism spectrum disorder symptoms. In Progress in Brain Research (pp. 37-62). (Progress in Brain Research; Vol. 241). Elsevier B.V.. https://doi.org/10.1016/bs.pbr.2018.09.014