Neuroimaging biomarkers of neurodegenerative diseases and dementia

Shannon L. Risacher, Andrew Saykin

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Neurodegenerative disorders leading to dementia are common diseases that affect many older and some young adults. Neuroimaging methods are important tools for assessing and monitoring pathological brain changes associated with progressive neurodegenerative conditions. In this review, the authors describe key findings from neuroimaging studies (magnetic resonance imaging and radionucleotide imaging) in neurodegenerative disorders, including Alzheimer's disease (AD) and prodromal stages, familial and atypical AD syndromes, frontotemporal dementia, amyotrophic lateral sclerosis with and without dementia, Parkinson's disease with and without dementia, dementia with Lewy bodies, Huntington's disease, multiple sclerosis, HIV-associated neurocognitive disorder, and prion protein associated diseases (i.e., Creutzfeldt-Jakob disease). The authors focus on neuroimaging findings of in vivo pathology in these disorders, as well as the potential for neuroimaging to provide useful information for differential diagnosis of neurodegenerative disorders.

Original languageEnglish
Pages (from-to)386-416
Number of pages31
JournalSeminars in Neurology
Volume33
Issue number4
DOIs
StatePublished - 2013

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Neuroimaging
Neurodegenerative Diseases
Dementia
Biomarkers
Alzheimer Disease
Prodromal Symptoms
Lewy Body Disease
Creutzfeldt-Jakob Syndrome
Prion Diseases
Huntington Disease
Amyotrophic Lateral Sclerosis
Multiple Sclerosis
Parkinson Disease
Young Adult
Differential Diagnosis
Magnetic Resonance Imaging
HIV
Pathology
Brain

Keywords

  • Alzheimer's disease (AD)
  • amyotrophic lateral sclerosis (ALS)
  • Cruetzfeldt-Jakob disease (CJD)
  • dementia
  • dementia with Lewy bodies (DLB)
  • frontotemporal dementia (FTD)
  • Gerstmann-Straussler-Scheinker disease (GSS)
  • HIV-associated neurocognitive disorder (HAND)
  • Huntington's disease (HD)
  • mild cognitive impairment (MCI)
  • multiple sclerosis (MS)
  • neuroimaging
  • Parkinson's disease (PD)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Neuroimaging biomarkers of neurodegenerative diseases and dementia. / Risacher, Shannon L.; Saykin, Andrew.

In: Seminars in Neurology, Vol. 33, No. 4, 2013, p. 386-416.

Research output: Contribution to journalArticle

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