Neuroimaging of Alzheimer's disease, mild cognitive impairment, and other dementias

Shannon L. Risacher, Andrew Saykin

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

The goal of the present chapter is to provide an overview of the major findings from studies of neuroimaging in dementia, particularly from patients with Alzheimer's disease (AD). The major emphasis is on findings from a variety of imaging modalities and the use of these measures for early diagnosis and as biomarkers of disease progression. In this chapter, we first describe the basic neurobiological changes and clinical symptoms associated with AD and related cognitive decline. Next, we discuss results from studies in AD utilizing structural neuroimaging techniques, including computerized tomography (CT), traditional structural magnetic resonance imaging (MRI), and other MRI techniques [diffusion tensor imaging (DTI), perfusion MRI, magnetic resonance spectroscopy (MRS)]. Next, we explore findings from functional MRI studies, including task-related activation studies and resting and functional connectivity research. We, then, discuss results from the use of nuclear medicine techniques in AD, including single-photon emission computerized tomography (SPECT) and positron emission tomography (PET) studies. Neuroimaging in other dementias is also briefly discussed, with particular emphasis on differential diagnosis of dementia type. Finally, we explore future directions for neuroimaging of early AD and dementia.

Original languageEnglish
Title of host publicationBrain Imaging in Behavioral Medicine and Clinical Neuroscience
PublisherSpringer New York
Pages309-339
Number of pages31
ISBN (Print)9781441963710
DOIs
StatePublished - 2011

Fingerprint

Neuroimaging
Dementia
Alzheimer Disease
Magnetic Resonance Imaging
Diffusion Tensor Imaging
Magnetic Resonance Angiography
Nuclear Medicine
Single-Photon Emission-Computed Tomography
Positron-Emission Tomography
Disease Progression
Cognitive Dysfunction
Early Diagnosis
Differential Diagnosis
Magnetic Resonance Spectroscopy
Biomarkers
Tomography
Research

ASJC Scopus subject areas

  • Psychology(all)

Cite this

Risacher, S. L., & Saykin, A. (2011). Neuroimaging of Alzheimer's disease, mild cognitive impairment, and other dementias. In Brain Imaging in Behavioral Medicine and Clinical Neuroscience (pp. 309-339). Springer New York. https://doi.org/10.1007/978-1-4419-6373-4_19

Neuroimaging of Alzheimer's disease, mild cognitive impairment, and other dementias. / Risacher, Shannon L.; Saykin, Andrew.

Brain Imaging in Behavioral Medicine and Clinical Neuroscience. Springer New York, 2011. p. 309-339.

Research output: Chapter in Book/Report/Conference proceedingChapter

Risacher, SL & Saykin, A 2011, Neuroimaging of Alzheimer's disease, mild cognitive impairment, and other dementias. in Brain Imaging in Behavioral Medicine and Clinical Neuroscience. Springer New York, pp. 309-339. https://doi.org/10.1007/978-1-4419-6373-4_19
Risacher SL, Saykin A. Neuroimaging of Alzheimer's disease, mild cognitive impairment, and other dementias. In Brain Imaging in Behavioral Medicine and Clinical Neuroscience. Springer New York. 2011. p. 309-339 https://doi.org/10.1007/978-1-4419-6373-4_19
Risacher, Shannon L. ; Saykin, Andrew. / Neuroimaging of Alzheimer's disease, mild cognitive impairment, and other dementias. Brain Imaging in Behavioral Medicine and Clinical Neuroscience. Springer New York, 2011. pp. 309-339
@inbook{43d9d449e72246d29fbc6729c2754fef,
title = "Neuroimaging of Alzheimer's disease, mild cognitive impairment, and other dementias",
abstract = "The goal of the present chapter is to provide an overview of the major findings from studies of neuroimaging in dementia, particularly from patients with Alzheimer's disease (AD). The major emphasis is on findings from a variety of imaging modalities and the use of these measures for early diagnosis and as biomarkers of disease progression. In this chapter, we first describe the basic neurobiological changes and clinical symptoms associated with AD and related cognitive decline. Next, we discuss results from studies in AD utilizing structural neuroimaging techniques, including computerized tomography (CT), traditional structural magnetic resonance imaging (MRI), and other MRI techniques [diffusion tensor imaging (DTI), perfusion MRI, magnetic resonance spectroscopy (MRS)]. Next, we explore findings from functional MRI studies, including task-related activation studies and resting and functional connectivity research. We, then, discuss results from the use of nuclear medicine techniques in AD, including single-photon emission computerized tomography (SPECT) and positron emission tomography (PET) studies. Neuroimaging in other dementias is also briefly discussed, with particular emphasis on differential diagnosis of dementia type. Finally, we explore future directions for neuroimaging of early AD and dementia.",
author = "Risacher, {Shannon L.} and Andrew Saykin",
year = "2011",
doi = "10.1007/978-1-4419-6373-4_19",
language = "English",
isbn = "9781441963710",
pages = "309--339",
booktitle = "Brain Imaging in Behavioral Medicine and Clinical Neuroscience",
publisher = "Springer New York",

}

TY - CHAP

T1 - Neuroimaging of Alzheimer's disease, mild cognitive impairment, and other dementias

AU - Risacher, Shannon L.

AU - Saykin, Andrew

PY - 2011

Y1 - 2011

N2 - The goal of the present chapter is to provide an overview of the major findings from studies of neuroimaging in dementia, particularly from patients with Alzheimer's disease (AD). The major emphasis is on findings from a variety of imaging modalities and the use of these measures for early diagnosis and as biomarkers of disease progression. In this chapter, we first describe the basic neurobiological changes and clinical symptoms associated with AD and related cognitive decline. Next, we discuss results from studies in AD utilizing structural neuroimaging techniques, including computerized tomography (CT), traditional structural magnetic resonance imaging (MRI), and other MRI techniques [diffusion tensor imaging (DTI), perfusion MRI, magnetic resonance spectroscopy (MRS)]. Next, we explore findings from functional MRI studies, including task-related activation studies and resting and functional connectivity research. We, then, discuss results from the use of nuclear medicine techniques in AD, including single-photon emission computerized tomography (SPECT) and positron emission tomography (PET) studies. Neuroimaging in other dementias is also briefly discussed, with particular emphasis on differential diagnosis of dementia type. Finally, we explore future directions for neuroimaging of early AD and dementia.

AB - The goal of the present chapter is to provide an overview of the major findings from studies of neuroimaging in dementia, particularly from patients with Alzheimer's disease (AD). The major emphasis is on findings from a variety of imaging modalities and the use of these measures for early diagnosis and as biomarkers of disease progression. In this chapter, we first describe the basic neurobiological changes and clinical symptoms associated with AD and related cognitive decline. Next, we discuss results from studies in AD utilizing structural neuroimaging techniques, including computerized tomography (CT), traditional structural magnetic resonance imaging (MRI), and other MRI techniques [diffusion tensor imaging (DTI), perfusion MRI, magnetic resonance spectroscopy (MRS)]. Next, we explore findings from functional MRI studies, including task-related activation studies and resting and functional connectivity research. We, then, discuss results from the use of nuclear medicine techniques in AD, including single-photon emission computerized tomography (SPECT) and positron emission tomography (PET) studies. Neuroimaging in other dementias is also briefly discussed, with particular emphasis on differential diagnosis of dementia type. Finally, we explore future directions for neuroimaging of early AD and dementia.

UR - http://www.scopus.com/inward/record.url?scp=84862821335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862821335&partnerID=8YFLogxK

U2 - 10.1007/978-1-4419-6373-4_19

DO - 10.1007/978-1-4419-6373-4_19

M3 - Chapter

AN - SCOPUS:84862821335

SN - 9781441963710

SP - 309

EP - 339

BT - Brain Imaging in Behavioral Medicine and Clinical Neuroscience

PB - Springer New York

ER -